Mechanical compression drives cancer cells toward invasive phenotype

By J. Tse, Gang Cheng, J. Tyrrell, Sarah A. Wilcox-Adelman, Y. Boucher, Rakesh K. Jain, Lance L. Munn. Proceedings of the National Academy of Sciences of the United States of America, 2011

597 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/a2dbeb0662e18800f3401823b4d884358acfe777

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Rakesh K. Jain
2. Triantafyllos Stylianopoulos
3. John D. Martin
4. Vikash P Chauhan
5. Lance L. Munn
6. Y. Boucher
7. Hadi Tavakoli Nia
8. Vasilis Ntziachristos

In Cell Biology

1. Rakesh K. Jain
2. Triantafyllos Stylianopoulos
3. John D. Martin
4. N. Bardeesy

In Oncology

1. Rakesh K. Jain
2. Triantafyllos Stylianopoulos
3. John D. Martin
4. Lance L. Munn
5. Y. Boucher
6. Vikash P Chauhan
7. N. Bardeesy
8. Dai Fukumura

Citations in the corpus

• Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. (2013, background): “In collaboration with Dr Lance Munn, we have shown that these compressive forces can also directly increase cancer cell invasion.(155) Thus, the tumors seem to use mechanical forces to aid progression and treatment resistance.”
• The role of mechanical forces in tumor growth and therapy (2014, unknown): “A | Intravital multiphoton microscopy images show treatment with the angiotensin receptor blocker, losartan lowers collagen levels (blue) and increases the density of perfused vessels (green) in an orthotopic mammary adenocarcinoma (EO771) [Reproduced from Reference (135)].”
• Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors (2012, background): “More recently, we have shown that the mechanical stress can also directly increase cancer cell invasion, aiding tumor progression (33).”
• Physical traits of cancer (2020, background): “Solid stress may also have additional, direct effects on tumor biology, such as promoting the invasiveness of cancer cells (19) and stimulating tumorigenic pathways in colon epithelia (20) (Fig.”
• ANTIANGIOGENESIS STRATEGIES REVISITED: FROM STARVING TUMORS TO ALLEVIATING HYPOXIA (2014, unknown): “The physical forces exerted by the tumor stroma can directly induce cancer cell invasion (Tse et al., 2012) and compress blood and lymphatic vessels.”