Altered microRNA expression in human heart disease.
By S. Ikeda, S. Kong, Jun Lu, E. Bisping, Hao Zhang, P. Allen, Todd R. Golub, B. Pieske, W. Pu. Physiological Genomics, 2007
672 citations recorded by the source corpus.
MicroRNAs are recently discovered regulators of gene expression and are becoming increasingly recognized as important regulators of heart function. Genome-wide profiling of microRNAs in human heart failure has not been reported previously. We measured expression of 428 microRNAs in 67 human left ventricular samples belonging to control (n = 10), ischemic cardiomyopathy (ICM, n = 19), dilated cardiomyopathy (DCM, n = 25), or aortic stenosis (AS, n = 13) diagnostic groups. miRNA expression between disease and control groups was compared by ANOVA with Dunnett's post hoc test. We controlled for multiple testing by estimating the false discovery rate. Out of 428 microRNAs measured, 87 were confidently detected; 43 were differentially expressed in at least one disease group. In supervised clustering, microRNA expression profiles correctly grouped samples by their clinical diagnosis, indicating that microRNA expression profiles are distinct between diagnostic groups. This was further supported by class prediction approaches, in which the class (control, ICM, DCM, AS) predicted by a microRNA-based classifier matched the clinical diagnosis 69% of the time (P < 0.001). These data show that expression of many microRNAs is altered in heart disease and that different types of heart disease are associated with distinct changes in microRNA expression. These data will guide further studies of the contribution of microRNAs to heart disease pathogenesis.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/5d1bc12f23a26da7ff5743662f5bf28ee1860203
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Citations in the corpus
- MicroRNAs in development and disease. (2011, background): “Early evidence that miRNAs were involved in cardiac pathology was attributed to the fact that they are differentially regulated during cardiac hypertrophy and failure in both rodent and human heart (102, 262, 407, 438, 533, 585, 600, 611, 626) (FIGURE 3).”
- The Role of MicroRNAs in Human Diseases (2010, background): “Recently, deregulated expression of miR-1 and miR-133 were reported in human heart failure (71, 79, 80) .”
- RNA silencing: Methods and protocols (2006, positive): “(Figure 1) MiRNAs are implicated in cardiac development and have been linked to the pathogenesis of a plethora of diseases and conditions, including HF.(4-5) The exact downstream molecular mechanisms by which miRNAs could influence disease development and progression are poorly understood.”