Macrophage plasticity, polarization, and function in health and disease

By A. Shapouri-Moghaddam, Saeed Mohammadian, H. Vazini, M. Taghadosi, Seyed-Alireza Esmaeili, Fatemeh Mardani, Bita Seifi, A. Mohammadi, J. T. Afshari, Amirhossein Sahebkar. Journal of Cellular Physiology, 2018

4,320 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/7677a1472e3bf84330738abc395755ce119c35f0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. A. Benito-Vicente
2. A. Larrea-Sebal
3. U. Galicia-Garcia
4. César Martín

In Immunology

1. F. Munari
2. R. Sánchez-Rodríguez
3. Tommaso Scolaro
4. A. Viola
5. Alessandra Castegna

Citations in the corpus

• Pathophysiology of Atherosclerosis (2022, background): “Macrophage plasticity is fundamental for a successful response with M1 predominating in disease progression and M2 in regression [142,146].”
• Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease (2019, background): “This is characterized by a polarization of adipose tissue macrophages towards the M1-like phenotype and increased proinflammatory cytokine production (Castoldi et al., 2015; Lackey and Olefsky, 2016; Shapouri-Moghaddam et al., 2018).”
• Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “The elimination of CAFs by FAP-targeting therapy can enhance the anticancer immune response mediated by high levels of certain inflammatory mediators, such as IFN-γ and TNF-α, and facilitate the toxic effects and metabolism of CD8 + T cells with a decreased desmoplastic stroma in the TME [224, 300, ”
• The Metabolic Signature of Macrophage Responses (2019, background): “Finally, M2d macrophages, also known as tumor-associated macrophages (TAMs), are induced by TLR ligands and A2 adenosine receptor (A2R) agonists, or by IL-6; they secrete high levels of IL-10, TGF-β, and VEGF and low IL12, TNF-α, and IL-1β, and contribute to tumor angiogenesis, growth and metastasis”
• Macrophage Polarization in Physiological and Pathological Pregnancy (2019, background): “Macrophages are classified into 2 subgroups (M1 and M2 [M2a, M2b, M2c, M2d]) depending on their anti- or pro-inflammatory properties (29).”