Humanin peptide suppresses apoptosis by interfering with Bax activation

By B. Guo, D. Zhai, E. Cabezas, K. Welsh, S. Nouraini, A. Satterthwait, John Calvin Reed. Nature, 2003

608 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/c46012a36d08b1543edc05893efd3e5bf3827e90

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Citations in the corpus

The Mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance (2015, positive): “Yet, humanin is currently the only reported mitochondrial-derived peptide (MDP) whose short open reading frame (sORF) maps to the mitochondrial DNA (mtDNA) (Guo et al., 2003; Hashimoto et al., 2001; Ikonen et al., 2003; Lee et al., 2013).”
Bcl-2 family members: intracellular targeting, membrane-insertion, and changes in subcellular localization (2004, background): “However, as for Ku70, reducing endogenous levels of Humanin only sensitized cells to apoptotic stimuli, and therefore a secondary step would be required for the activation of Bax [73].”
The Bcl-2 family: roles in cell survival and oncogenesis (2003, background): “…(see above), some recent work has suggested that in healthy cells Bax might be sequestered in the cytosol by another protein: a 14-3-3 protein (Nomura et al., 2003); the Ku70 protein, otherwise involved in DNA repair in the nucleus (Sawada et al., 2003); or the Humanin peptide (Guo et al., 2003).”
Ways of dying: multiple pathways to apoptosis. (2003, background): “Bax, for example, might be sequestered in the cytosol of healthy cells by one of several putative new binding partners (Guo et al. 2003; Nomura et al. 2003; Sawada et al. 2003).”
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. (2005, background): “release of cyto-c and activation of caspase-9 (Guo et al., 2003; Wei et al., 2001).”
Role of Bcl-2 family proteins and caspases in the regulation of apoptosis (2011, background): “A number of therapeutic approaches are undergoing using an antisense RNA [208], various small molecules [209–218, 222, 223], and peptidic compounds [219–221, 224, 225] classified as potential therapeutics to target the pathway of apoptosis, as briefly summarized in Table 2.”
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. (2005, background): “For example, family proteins, although regulatory partners outside the family may also be important (Chipuk et al., 2004; Cud-E -Myc tumor cells can undergo apoptosis when Bcl-2 is downregulated (Letai et al., 2004). deback et al., 2001; Guo et al., 2003; Sawada et al., 2003).”