Nod-like proteins in immunity, inflammation and disease

By Jörg H. Fritz, R. Ferrero, D. Philpott, S. Girardin. Nature Immunology, 2006

931 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/c3f80dcb74b5bc6426a05f6668ccac1dd7a4ddc8

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Citations in the corpus

The perfect mix: recent progress in adjuvant research (2007, background): “NOD proteins and NLRs have in common a C-terminal leucine-rich-repeat (LRR) domain, a central nucleotide-binding domain and N-terminal protein–protein interaction CARD (caspase activation and recruitment domain) and pyrin or BIR (baculovirus inhibitor-of-apoptosis repeat) domain”
Caspases in apoptosis and beyond (2008, background): “In mammals, the homologs of CED-9, CED-4 and CED-3 are present in the Bcl-2 family, Apaf-1/NOD-like receptor family and caspase (cysteinyl aspartate proteinases) family, respectively (Miura et al., 1993; Zou et al., 1997; Gross et al., 1999; Fritz et al., 2006).”
A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation (2008, background): “Members of the nucleotide-binding domain-like receptor (NLR) protein family are found in both mammals and plants (Inohara et al, 2005; Fritz et al, 2006).”
Common disorders are quantitative traits (2009, background): “The search for the mechanisms by which these genes affect the disorder is leading to quantitative traits, such as inflammatory respons”
Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome (2008, background): “This complex is activated by multiple agonists including a bacterially derived muramyl dipeptide or endogenous ATP and uric acid, leading to the processing and release of IL-1 (10, 11).”
Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion (2008, background): “NOD proteins and NLR proteins represent a class of intracellular receptors that share a conserved domain structure and sense a wide variety of PAMPs and other danger signals (78, 292).”
Activation of innate immune antiviral response by NOD2 (2009, background): “A third class of PRR includes members of the nucleotide-binding domain (NBD)– and leucine-rich-region (LRR)–containing family of cytoplasmic proteins (known as NLRs); these proteins respond to bacterial PAMPs to activate the transcription factor NF-κB and mitogen-activated protein kinase pathway”
Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome (2010, background): “The NLR (nucleotide-binding domain and leucine-rich repeat-containing) family comprises a group of intracellular pattern recognition receptors. NLRs have a leucine-rich repeat (LRR) that recognises diverse pathogen-associated molecular patterns.”
Antimicrobial activity of mucosal-associated invariant T cells (2010, background): “The induction of immunological responses by a highly conserved microbe-derived product is reminiscent of the ligands of the innate immune syste”
Antigen-presenting cell function in the tolerogenic liver environment (2010, background): “NOD2 is a PRR that mediates resistance to microbial infection and regulates innate and adaptive immune response”