A Neural Circuit for Gut-Induced Reward.

By Wenfei Han, Luis A. Tellez, Matthew H. Perkins, Isaac O. Perez, Taoran Qu, J. Ferreira, T. L. Ferreira, Danielle Quinn, Zhong-Wu Liu, Xiao-Bing Gao and 5 more. Cell, 2018

651 citations recorded by the source corpus.

The gut is now recognized as a major regulator of motivational and emotional states. However, the relevant gut-brain neuronal circuitry remains unknown. We show that optical activation of gutLead Corresponding Author: Ivan E de Araujo, Present address: Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York NY, USA, Ivan.DeAraujo@mssm.edu. Author Contributions I.E.d.A. conceived study. I.E.d.A., W.H., L.A.T., S.J.S.-L., G.d.L. designed experiments. G.d.L. developed viral approach to nodose. W.H., T.Q., G.d.L. performed gastrointestinal and vagal injections, histology. W.H., L.A.T., M.H.P., T.L.F. J.F. performed stereotaxic surgeries, behavioral, electromyogram and optogenetic experiments, analyzed data. D.Q. performed satiation assays. W.H., S.J.S.-L. performed tracing, histology, imaging. D.V.B., M.M.K. packaged rabies constructs. Z.L., X.G. performed whole-cell patch-clamp experiments, analyzed data. L.A.T. W.H., M.P., I.O.P. performed in vivo electrophysiology, analyzed nerve recordings, single-unit data. I.E.d.A. wrote manuscript. All authors interpreted all data, edited manuscript. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Declaration of Interests The authors declare no competing interests. HHS Public Access Author manuscript Cell. Author manuscript; available in PMC 2019 October 18. Published in final edited form as: Cell. 2018 October 18; 175(3): 665–678.e23. doi:10.1016/j.cell.2018.08.049. A uhor M anscript

Subfields: Endocrine and Autonomic Systems, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/d2e8edaad51d620449e656773606977113b1f07e