Induction and effector functions of TH17 cells
By E. Bettelli, T. Korn, M. Oukka, V. Kuchroo. Nature, 2008
1,258 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/c3bc46a5b1a2e08b8445b91f873cf557b6dddc85
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In Immunology
- TA Wynn
- J. O’Shea
- Li-Fan Lu
- Steven Z. Josefowicz
- Alexander Y. Rudensky
- A. Jetten
- M. Wilson
- F. Powrie
Citations in the corpus
- Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “The latter differentiation pathway is favored when TCR and TGF-βR activation in naive CD4+ T cells coincides with IL-6R stimulation (122).”
- Control of regulatory T cell lineage commitment and maintenance (2009, background): “The latter differentiation pathway is favored when TCR and TGF-bR activation in naive CD4+ T cells coincides with IL-6R stimulation (Bettelli et al., 2008).”
- Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis (2010, background): “In addition to previously recognized T helper 1 (Th1) and Th2 fates, naive CD4 T cells can also differentiate into Th17 and regulatory T (Treg) cells; the balance of Th17 and Treg cells is now considered to be critical for host immunity and the preservation of tolerance (Bettelli et al., 2008; Stock”
- Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “The recently discovered Th17 cells produce IL-17A (IL-17), IL-17F, IL-21, and IL-22 as major cytokines, while Treg cells synthesize IL-10 and TGFβ1 [Bettelli et al., 2008; Chen and O'Shea, 2008; Dong, 2008; Harrington et al., 2006; Park et al., 2005].”
- Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 (2011, background): “Dysregulated auto-antigen–specific T H 1 responses are believed to be involved in organ-specific autoimmune diseases, and T H 17 cells have been increasingly recognized to contribute to host defense and induction of autoimmunity and tissue inflammatio”
- Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent (2010, background): “, 2006), which regulate the pathogenesis of a variety of autoimmune and inflammatory diseases (Bettelli et al., 2008).”