What is the role of protein aggregation in neurodegeneration?

By Christopher A. Ross, Michelle A. Poirier. Nature reviews. Molecular cell biology, 2005

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Oxidative stress in ALS: key role in motor neuron injury and therapeutic target. (2010, background): “…aggregates is a common pathological feature of many neurodegenerative diseases, including ALS, although whether they play a role in disease pathogenesis, are harmless byproducts , or represent a defense mechanism by sequestration of harmful intracellular proteins is not known [137] [138] [139].”
The roles of intracellular protein-degradation pathways in neurodegeneration (2006, background): “Whether soluble monomers, oligomers or larger aggregates are the most toxic species causing many of these conditions has been the subject of considerable debate and uncertainty (for a discussion, see ref”
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. (2007, background): “Received: January 5, 2007 Revised: June 26, 2007 Accepted: October 9, 2007 Published: December 13, 2007”