PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

By G. Chinetti, S. Lestavel, V. Bocher, A. Remaley, B. Neve, I. Torra, E. Teissier, A. Minnich, M. Jaye, N. Duverger and 4 more. Nature Medicine, 2001

904 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/c2e4aea8c05a1444492c547a4e27c7c959162e65

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. S. Kersten
2. Mitchell A. Lazar
3. D. Moller
4. M. Lehrke
5. D. Cohen
6. Y. Kawano
7. David J. Loane
8. Alok Kumar

In Surgery

1. Mitchell A. Lazar
2. S. Kersten

Citations in the corpus

• The mechanisms of action of PPARs. (2002, background): “Two recent studies have suggested that either PPARα (154) or PPARγ (154, 155) activation in macrophages can induce the expression of a cholesterol efflux “pump” known as ABC-A1.”
• The many faces of PPARgamma. (2005, positive): “The solution to the paradox of PPARγ increasing lipid uptake in macrophages without increasing atherosclerotic risk has focused on the activation of lipid efflux pathways, such as reverse cholesterol transport, that prevent atherosclerotic lipid accumulation (Chawla et al., 2001a; Chinetti et al., 2”
• Peroxisome Proliferator-Activated Receptor Alpha Target Genes (2010, background): “Presently, it is not clear if this effect of PPARα activation is mediated via LXRα, as was shown previously in macrophages [21].”