AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli
By P. Falnes, Rune Forstrøm Johansen, Erling Seeberg. Nature, 2002
607 citations recorded by the source corpus.
Subfields: Genetics, Inorganic Chemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c2dc7adce3c0ff840a6c1a00fe14ddab594f5188
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Citations in the corpus
- Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. (2008, background): “2007) and the previously identified AlkbH enzymes (Falnes et al. 2002; Trewick et al. 2002) that catalyze the removal of methyl groups from alkylated nucleotides.”
- An epigenetic road map for histone lysine methylation (2003, background): “Although intermediary enzymes could destabilise the amino-methyl bond by oxidation or radical attack (Chinenov, 2002; Falnes et al., 2002; Trewick et al., 2002), reversion of an engaged chromatin region to a more naive state might instead be triggered by transcription-coupled histone replacement,…”
- Active DNA Demethylation Mediated by DNA Glycosylases (2009, neutral): “The Alkb family of enzymes can remove the methyl group from 1-methyladenine and 3-methylcytosine by oxidative demethylation, employing Fe(II) and alpha-ketoglutarate as cofactors, and release the methyl moiety as formaldehyde (24, 95).”
- Active DNA demethylation: many roads lead to Rome (2010, background): “Using oxygen, iron and 2OG as cofactors, AlkB is able to carry out oxidative demethylation of 1-methyladenine and 3meC by releasing the methyl group as formaldehyd”
- Mechanisms of human DNA repair: an update. (2003, background): “Instead it shares similarity with a superfamily of 2-oxoglutarate-and iron-dependent dioxygenases (Falnes et al., 2002; Trewick et al., 2002).”
- JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. (2006, methodology): “In an effort to identify histone demethylases that differ from the LSD1 family of proteins, we have developed an in vitro histone demethylase assay based on the mechanism used by the DNA repair demethylase AlkB (Falnes et al., 2002; Trewick et al., 2002).”
- Alkylation damage in DNA and RNA--repair mechanisms and medical significance. (2004, background): “Shortly later two groups were able to confirm the predicted enzyme activity [45,46].”
- DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy (2021, background): “In 2002, studies by Pal F et al.(240)and Sarah CT et al.”
- Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA (2003, background): “Alkylation damage in DNA is repaired by at least three different mechanisms, including damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine by Escherichia coli Alk”
- Histone demethylation by a family of JmjC domain-containing proteins (2006, background): “In addition, our study also indicates that histone demethylation catalysed by JmjC domain proteins uses the same oxidative demethylation mechanism used by the AlkB family of DNA demethylases 11,12 .”
- Oxygen sensing by HIF hydroxylases (2004, background): “The precise definition of the in vivo roles of ascorbate is of increasing interest, not only because of its potential involvement in the hypoxic response, but also because of its possible role in DNA repair through stimulation of the 2-oxoglutarate-dependent-oxygenase Alk”
- Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related Enzymes (2004, background): “, 2002), thus resulting in release of replication blocks (Falnes et al., 2002).”