Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

By P. A. Aas, M. Otterlei, P. Falnes, C. Vågbø, F. Skorpen, Mansour Akbari, O. Sundheim, M. Bjørås, G. Slupphaug, Erling Seeberg and 1 more. Nature, 2003

624 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/724ffa1a43ecf34b7ffdcaae4be66cff3bd0a8b5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Repair and genetic consequences of endogenous DNA base damage in mammalian cells. (2004, background): “F or p er so na l u se o nl y. P1: JRX October 18, 2004 14:55 Annual Reviews AR230-FM vi CONTENTS METAGENOMICS: GENOMIC ANALYSIS OF MICROBIAL COMMUNITIES, Christian S. Riesenfeld, Patrick D. Schloss, and Jo Handelsman 525 GENOMIC IMPRINTING AND KINSHIP: HOW GOOD IS THE EVIDENCE?, David Haig 553 MECH”
Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related Enzymes (2004, background): “…for alkB mutants on reactivation of methylated double-stranded phage (lambda and M13), pronounced deficiencies were noted for reactivation of the methylmethanesulfonate-treated single-stranded DNA viruses (M13, f1, and G4) (Dinglay et al., 2000) and a single-stranded RNA virus (Aas et al., 2003).”
Alkylation damage in DNA and RNA--repair mechanisms and medical significance. (2004, background): “[10], and that hABH2 has a preference for double-stranded DNA, whereas AlkB and hABH3 acts more efficiently on single-stranded nucleic acids.”
13 reasons why the brain is susceptible to oxidative stress (2018, neutral): “alkylation [274] at Watson-Crick interfaces.”
Mechanisms of human DNA repair: an update. (2003, background): “As already mentioned, in E. coli, pre-mutagenic DNA alkylation damage is reverted by the adaptive response system comprising the proteins Ada and AlkB.”