Making sense of latent TGFbeta activation.

By Justin P. Annes, J. Munger, D. Rifkin. Journal of Cell Science, 2003

902 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c285481325f945c75335388ec346604183c8b2ae

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Citations in the corpus

Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. (2018, background): “MMPs also activate transforming growth factor-h (TGF-h) by cleaving off the latency-associated peptide (Annes et al., 2003).”
Transforming Growth Factor (TGF)-β signaling in cardiac remodeling (2010, unknown): “Activation of a small fraction of latent TGF-β is capable of generating maximal cellular response [2].”
TGF-β signaling in fibrosis (2011, background): “Owing to the high affinity between TGF-b and its receptors, activation of only a small fraction of this latent TGF-b generates maximal cellular response (Annes et al. 2003).”
Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix (2007, unknown): “…can be found at: JCB • VOLUME 179 • NUMBER 6 • 2007 1312 binding to other ECM components like fi brillin-1 and fi bronectin (FN; Unsold et al., 2001; Annes et al., 2003; Hyytiainen et al., 2004; Koli et al., 2005), of which ED-A FN is the major splice variant expressed by Mfs (Serini et al.,…”
Fibronectin is required for integrin o:vβ6‐mediated activation of latent TGF‐β complexes containing LTBP‐1 (2005, background): “Cells secrete a significant amount of latent TGF- , but only a small fraction is activated (49, 50).”
The PD-1 Pathway in Tolerance and Autoimmunity (2010, background): “Following post-translational processing, TGF-b binds latency-associated peptide (LAP) to maintain TGF-b in its inactive form (105).”
Targeting TGF-β signal transduction for fibrosis and cancer therapy (2022, background): “Others believed that the regulation of TGF-β activation by GARP required the release and diffusion of mature TGF-β [33].”
TGF-beta and fibrosis in different organs - molecular pathway imprints. (2009, background): “The disulfide-bound latent-TGF-βbinding proteins 1/2 (LTBP 1/2) connect the whole complex to the ECM (details described in [6]).”
The role of TGF-β Signaling in Myocardial Infarction and Cardiac Remodeling (2007, unknown): “/74 /2/184/28 Keywords: Fibrosis; Growth factors; Infarction; Remodeling; Cytokines 3885 by guest on 30 O ctober 2018”
The Pathogenesis of Cardiac Fibrosis (2013, unknown): “Following cardiac injury, the extracellular concentration of TGF-β activity is regulated primarily through conversion of the latent to the active form; activation of a relatively small amount of latent TGF-β is sufficient to induce a maximal cellular response [226].”
Formation and function of the myofibroblast during tissue repair. (2007, background): “by plasmin) and by the action of thrombospondin-1 (Annes et al., 2003).”
TGF‐β signaling and the fibrotic response (2004, background): “This process has been extensively reviewed elsewhere (18).”
The myofibroblast matrix: implications for tissue repair and fibrosis (2013, unknown): “In mammals, these functions are mediated by the widely expressed three isoforms TGF-β1, TGF-β2, and TGF-β3 that are encoded by three different genes of high homology [119].”