TGF‐β signaling and the fibrotic response

By A. Leask, David J. Abraham. The FASEB Journal, 2004

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Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy. (2012, background): “Connective tissue growth factor (CTGF) is a highly profibrogenic molecule which is overexpressed in many fibrotic lesions [83,84].”
Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury (2010, unknown): “TGF-β1 is a well-established principal driver of fibrosis via promotion of fibroblast proliferation, extracellular matrix synthesis and inhibition of collagenases in multiple organ”
Progress in corneal wound healing (2015, background): “This temporary ECM appears to be accumulated by a TGF-βdependent mechanism (Leask and Abraham, 2004).”
TGF-β signaling in fibrosis (2011, background): “TGF-b signaling pathways in fibrosis Animal model experiments have suggested an important in vivo role for TGF-b in the pathogenesis of fibrotic conditions (Leask and Abraham 2004; Pohlers et al. 2009).”