Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

By J. MacMicking, G. A. Taylor, J. Mckinney. Science, 2003

678 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/c24906e96ff1fb4d3540a31d62749733bdd816d0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. V. Deretic
2. J. Cox
3. R. Watson
4. P. Manzanillo
5. Marina Colombo
6. A. O’Garra
7. Stefan H. E. Kaufmann
8. Beth Levine

In Oncology

1. V. Deretic
2. J. Cox
3. R. Watson
4. P. Manzanillo
5. Stefan H. E. Kaufmann
6. Beth Levine

In Pathology and Forensic Medicine

1. V. Deretic
2. J. Cox
3. R. Watson
4. P. Manzanillo

Citations in the corpus

• Mycobacterium tuberculosis: Success through dormancy (2012, background): “0 (Sturgill-Koszycki et al., 1996; MacMicking et al., 2003; Yates et al., 2005).”
• The immune response in tuberculosis. (2013, background): “tuberculosis infection include LRG-47, an IFNinducible GTP-binding protein (275).”
• Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. (2004, background): “tuberculosis infection and that this effect was independent of autophagy promotes mycobacterial phagosome maturation and associated intracellular killing of the pathoproduction of reactive nitrogen and oxygen intermediates (MacMicking et al., 2003).”
• Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. (2007, background): “Furthermore, LPS upregulated LRG47, a GTPase that has been recently shown to be involved in antimycobacterial effects through contribution to autophagy induction (MacMicking et al., 2003; Gutierrez et al., 2004).”
• Autophagy, Immunity, and Microbial Adaptations (2009, result): “The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.”
• Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway (2012, positive): “Although inducing autophagy exogenously via starvation, treatment with rapamycin, interferon gamma (IFN-g), or vitamin D3 or genetic depletion of autophagy inhibitors can lead to decreased bacterial replication in macrophages (Gutierrez et al., 2004; Kumar et al., 2010; Singh et al., 2006; Yuk et al”