Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages.

By M. Gutierrez, Sharon S. Master, Sudha Singh, G. A. Taylor, Marina Colombo, V. Deretic. Cell, 2004

2,311 citations recorded by the source corpus.

Subfields: Endocrinology, Epidemiology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/20305acf44b22c07e7f8dc52b57cf36ae0b6e6d2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. N. Mizushima
2. Beth Levine
3. D. Klionsky
4. V. Deretic
5. Guido Kroemer
6. L. Galluzzi
7. Congcong He
8. G. Núñez

In Epidemiology

1. Beth Levine
2. Guido Kroemer
3. N. Mizushima
4. D. Klionsky
5. I. Slaninová
6. V. Deretic
7. L. Galluzzi
8. D. Rubinsztein

In Infectious Diseases

1. Beth Levine
2. D. Klionsky
3. N. Mizushima
4. A. O’Garra
5. G. Núñez
6. Guido Kroemer
7. R. Wilkinson
8. V. Deretic

Citations in the corpus

• TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation (2012, neutral): “Rab8b knockdown caused a decrease in conversion of BCG phagosomes to degradative compartments after induction of autophagy (Gutierrez et al., 2004; Ponpuak et al., 2010) (Figures 1B–1D) and autophagic killing of mycobacteria (Figure 1E).”
• Toll‐like receptors control autophagy (2008, methodology): “NF-kB-responsive luciferase reporter plasmid PathDetects NF-kB cis-Reporting System was from Stratagene (La Jolla, CA, USA) and the b-galactosidase construct, pEF1-Bos, was from G Nunez (University of Michigan).”
• Antimicrobial mechanisms of phagocytes and bacterial evasion strategies (2009, background): “tuberculosis -containing phagosomes are sequestered by autophagic compartments that ultimately fuse with lysosome”
• Autophagy: a lysosomal degradation pathway with a central role in health and disease. (2009, background): “somes, but induction of autophagy bypasses the maturation defect, leading to phagolysosome formation and bacterial killing [108].”
• Subversion of Cellular Autophagosomal Machinery by RNA Viruses (2005, methodology): “For example, induction of autophagy has been shown to promote clearance of Mycobacterium tuberculosis from infected macrophage [ 66 ].”
• Autophagy in inflammation, infection, and immunometabolism (2021, background): “Anti-viral autophagy When autophagy had been recognized in a systematic fashion as a bona fide immune process (Deretic, 2005; Levine, 2005), this was to a large extent prompted by findings that autophagy can eliminate a variety of intracellular bacteria such as Mycobacterium tuberculosis (Mtb) (Guti”
• Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, positive): “tuberculosis (Gutierrez et al., 2004a). Yu et al. (2006) showed that autophagy selectively degraded catalase leading to the”
• Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. (2007, methodology): “…component of innate immunity (Kirkegaard et al., 2004) and is involved in the host defense elimination of bacterial pathogens including Group A Streptococcus (Nakagawa et al., 2004), Shigella flexneri (Ogawa et al., 2005) and Mycobacterium tuberculosis (Gutierrez et al., 2004; Singh et al., 2006).”