Cancer epigenetics: from mechanism to therapy.

By M. Dawson, Tony Kouzarides. Cell, 2012

3,020 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2bf6c6de39bf3ef961a07b8ab851924a73164bd1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Genomic basis for RNA alterations in cancer (2020, background): “Further work is needed to investigate other mechanisms of genome alteration that can lead to changes in RNA such as epigenetic changes 56 or enhancer hijacking 57 .”
Genetics and biology of prostate cancer (2018, background): “, methylation and hydroxymethylation), histone modification, or nucleosome remodeling can drive tumorigenesis in many cancer types (Dawson and Kouzarides 2012; Feinberg et al. 2016; Flavahan et al. 2017; Genovese et al. 2017), including prostate cancer (Albany et al.”
The physics of epigenetics (2015, background): “Because of this intricate history, a consensus definition of epigenetics is still lacking today (Dawson and Kouzarides, 2012).”
Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018, background): “Many reports have demonstrated that epigenetic alterations play important roles in driving cancer initiation and progression [123, 124].”
Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity (2020, background): “HDAC expression is altered in a number of cancers and several HDAC inhibitors were tested for cancer treatment alone or in combination with other therapies [175,199].”
Erasers of histone acetylation: the histone deacetylase enzymes. (2014, background): “Somatic mutations in DNA and histone-modifying enzymes contribute to human malignancies (Dawson and Kouzarides 2012), and HDACs are no exception.”