The functions of animal microRNAs

By V. Ambros. Nature, 2004

10,833 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c1d5adbe76bb3b72c71ed930272dec2a3a917f76

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis (2011, background): “MicroRNAs (miRNAs) are small, noncoding, 21-nucleotide-long to 23-nucleotide-long RNAs that negatively regulate gene expression by base pairing with the 3-untranslated region of their target messenger RNAs (mRNAs).(2) If pairing is perfect or nearly perfect, target mRNAs are degraded (predominantly ”
Genome-wide identification and analysis of drought-responsive microRNAs in Oryza sativa. (2010, background): “, 1993), the number of identified miRNAs in plants and animals has expanded rapidly (Ambros, 2004; Sunkar et al., 2005; Jones-Rhoades et al., 2006; Zhang et al., 2006; Pilcher et al., 2007; Xie et al., 2007; Sunkar and Jagadeeswaran, 2008).”
Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. (2005, background): “This is the mechanism used by endogenously produced microRNAs (miRNA), believed to be another method of natural regulation of gene expression (47).”
Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. (2008, background): “…an important new class of regulatory biomolecules, with roles in processes as diverse as early development, cell proliferation and differentiation, apoptosis , fat metabolism, and oncogenesis (for reviews, see Ambros 2004; Bartel 2004; Esquela-Kerscher and Slack 2006; Calin and Croce 2006a).”
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “They represent one of the most exciting areas of modern medical sciences as they possess unique ability to modulate an immense and complex regulatory network of gene expression [6, 7] in a broad spectrum of developmental and cellular processes including tissue development [8, 9], cell proliferation ”
miRDB: an online database for prediction of functional microRNA targets (2019, background): “MicroRNAs (miRNAs) are small noncoding RNAs that regulate many biological processes (1,2).”
Making or breaking the heart: from lineage determination to morphogenesis. (2006, background): “miRNAs are genomically encoded 20–22 nucleotide RNAs that target mRNAs for translational inhibition or degradation by many of the same pathways as small interfering (si)RNAs (He and Hannon, 2004; Ambros, 2004).”
MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma. (2011, background): “Thus, depending on the target mRNAs, miRNAs are responsible for the control of various biological functions including cell proliferation, apoptosis, differentiation, metabolism, oncogenesis and oncogenic suppressio”
Modulation of microRNA processing and expression through RNA editing by ADAR deaminases (2006, background): “After integration into the RNA-induced silencing complex (RISC), miRNAs block translation of specific mRNAs containing partially complementary targets located in the 3′ untranslated regions or guide degradation of target mRNAs (as do siRNAs”