Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis

By C. Roderburg, Gerd Urban, K. Bettermann, M. Vucur, H. Zimmermann, Sabine Schmidt, Jörn Janssen, C. Koppe, P. Knolle, M. Castoldi and 3 more. Hepatology, 2011

787 citations recorded by the source corpus.

Subfields: Cancer Research, Hepatology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/453a21a9563e4ba29581bec117a3e1308c18d902

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Maria-Teresa Piccoli
2. J. Beermann
3. S. Friedman
4. B. Hinz
5. J. Viereck
6. Thomas Thum

In Hepatology

1. Y. Saiman
2. J. Puche
3. S. Friedman
4. B. Hinz
5. J. Bonner
6. Nikolaos G. Frangogiannis

In Molecular Biology

1. B. Hinz
2. O. De Wever
3. M. Mareel
4. Maria-Teresa Piccoli
5. J. Beermann
6. S. Friedman
7. J. Viereck
8. Thomas Thum

Citations in the corpus

• Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “As a matter of fact, miR-29 downregulation in hepatic stellate cells is dependent on TGF- 1 and NF- B signaling and leads to the upregulation of extracellular matrix genes (230).”
• Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. (2012, background): “A comparable fibrosis-suppressing role has been demonstrated for miR-200a in the kidney(49) and liver.(47) Conversely, in an animal model of kidney fibrosis, upregulation of miR-192 is reported on TGF 1 signaling, and overexpression of an miR-192 analogue induces ECM production.”
• Hepatic Stellate Cells and Liver Fibrosis (2013, positive): “-27b and miR29b are upregulated in activated stellate cells, whereas their suppression leads to decreased proliferation and an increase in lipid droplets indicative of the quiescent phenotype (205, 244).”