Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

By Jason C. O'Connor, M. Lawson, Caroline André, Maïté M. Moreau, J. Lestage, N. Castanon, Keith W. Kelley, Robert Dantzer. Molecular Psychiatry, 2009

1,242 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Social Psychology

View Paper: https://www.semanticscholar.org/paper/c1d11d07b890e75a4d43315b97f06b4664cbb0ff

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Citations in the corpus

Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, methodology): “Abbreviations ACC Anterior Cingulate Cortex ACTH Adrenocorticotropic Hormone BCG Bacille Calmette-Guerin BDNF Brain Derived Neurotrophic Factor BH4 Tetrahydrobiopterin BMI Body Mass Index CNS Central Nervous System COX Cyclooxygenase CRH Corticotropin-Releasing Hormone Pharmacol Ther.”
Depression as a microglial disease. (2015, background): “However, another study found no antidepressant-like effects of minocycline (albeit at somewhat lower doses) in the forced swim test [87]; (ii) in the LPS model of depression in rats, administration of minocycline completely prevented the development of depression-like symptoms, as well as the LPS-in”
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression (2009, positive): “For example, administration of KYN alone has been shown to induce depressive-like behavior in mice (28).”
Minocycline: far beyond an antibiotic (2013, background): “In that report, minocycline’s ability to block IDO induction prevented depressive-like immobility (O’Connor et al., 2009).”
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. (2016, background): “…3-dioxygenase (IDO), an enzyme induced by cytokines, and tryptophan-2,3-dioxygenase (TDO), the expression of which can be induced by circulating glucocorticoids (O'Connor et al., 2009) and has been reported to be regulated by the gut microbiota during colonization (El Aidy et al., 2014).”
Cytokine Targets in the Brain: Impact on Neurotransmitters and Neurocircuits (2013, methodology): “of both the administration of endotoxin and infection with the mycobacterium, Bacille Calmette-Guerin (BCG).[56,57] Indeed, inhibition of IDO using 1 methyl-tryptophan (1-MT) or the use of IDO deficient mice has been shown to reverse the depressogenic effects of endotoxin and BCG in mice.”
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression (2009, neutral): “(O”Connor et al. 2008).”
From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression (2014, background): “…for this tryptophan depletion hypothesis of depression is provided by animal model studies, which have shown that depressive-like behaviors in rodents are mediated by an enzyme that degrades tryptophan, called indoleamine 2,3-dioxygenase (IDO; O’Connor et al., 2009; see also Maes et al., 2011).”