Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.

By A. Uren, K. O'Rourke, L. Aravind, M. T. Pisabarro, S. Seshagiri, E. V. Koonin, V. M. Dixit. Molecules and Cells, 2000

1,120 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/c1a4c3588f68dccb5354bfc840bd21f806676498

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. V. Dixit
2. J. Ameisen

In Molecular Biology

1. C. Brussaard
2. Jeffery L. Dangl
3. V. Dixit
4. P. Epple
5. J. Ameisen
6. N. Coll
7. T. Kanneganti

Citations in the corpus

• What is the role and nature of programmed cell death in phytoplankton ecology? (2006, background): “One should note however, that genes encoding for proteins known as ‘paracaspases’ (bacteria) and ‘metacaspases’ (plants and fungi) have been recognized from sequence work, and that all these enzymes share common active sites (Uren et al , 2000 ).”
• Programmed cell death, mitochondria and the plant hypersensitive response (2001, background): “, which act by inhibiting caspases, a family of cysteine proteases that serve as the critical switch for many forms of PCD in animal cell”
• Bcl10 activates the NF-κB pathway through ubiquitination of NEMO (2004, background): “Bcl10 or its viral homologue E10 have been reported to interact with paracaspase/MALT1, cIAPs (inhibitor of apoptosis proteins) and TRAFs, but how these interactions affect Bcl10-induced NF-κB activation is unclea”
• On the origin, evolution, and nature of programmed cell death: a timeline of four billion years (2002, background): “Recently, however, genes encoding caspase-like proteins, the metacaspases, that are not present in animals and appear to belong to an ancestral caspase/paracaspase/ metacaspase superfamily, have been identified in plants.(111) Interestingly, a plant metacaspase shares a domain with a protein involve”
• NF‐κB and the link between inflammation and cancer (2012, neutral): “of CARD11) to yield IKK activation (88).”
• Programmed cell death in the plant immune system (2011, background): “Paracaspases have been found in animals and slime molds, whereas metacaspases are present in plants, fungi, protozoa and cyanobacteria.(92) These cysteine proteases differ from caspases in their substrate specificity; caspases cleave their targets after an aspartate residue, while paracaspases are a”