Calcium: Regulation of cell death: the calcium–apoptosis link
By S. Orrenius, B. Zhivotovsky, P. Nicotera. Nature reviews. Molecular cell biology, 2003
2,968 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/c1343a697f7fcebef69829b00510b99d12be5124
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Citations in the corpus
- Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances (2025, positive): “235,236 Calcium/calmodulin-dependent protein kinase can be activated by high calcium concentration, and then phosphorylates Serine616 on Drp1.”
- MICU1 is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake That Regulates Cell Survival (2012, positive): “Ca2+ flux across the inner mitochondrial membrane (IMM) regulates cell bioenergetics, cytoplasmic Ca2+ ([Ca]i) signals and activation of cell death pathways (Balaban, 2009; Denton and McCormack, 1980; Duchen et al., 2008; Gunter and Gunter, 1994; Hajnoczky et al., 1995; Hansford, 1994; Herrington et”
- Bcl-2 family proteins and cancer (2008, background): “…(e) Ca2þ -sensitive isoforms of nitric oxide synthase, thereby generating reactive nitrogen species and contributing to oxidative stress (reviewed by Orrenius et al., 2003; Benhar et al., 2006); (g) Ca2þ-binding protein TCTP (fortilin), a putative modulator of antiapoptotic Bcl-2/ Bax-family…”
- Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis (2003, background): “jpg" NDATA ITEM> ]> Calcium signalling mediates many cellular functions, including programmed cell death through influences on free radical production, organelle disruption and proteolytic enzyme activatio”
- Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis (2008, background): “Indeed, it is becoming increasingly appreciated that ER-mitochondrial calcium signaling is crucial in several models of apoptosis (Demaurex and Distelhorst, 2003; Orrenius et al., 2003; Rizzuto et al., 2003; Scorrano et al., 2003).”
- Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. (2008, background): “1 m in the cytosol) (73, 74), a relatively oxidative state favoring disulfide bond formation by protein sulfide isomerases (75), and a protein quality control system (76, 77).”