Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

By D. Boehning, R. Patterson, L. Sedaghat, N. Glebova, T. Kurosaki, S. Snyder. Nature Cell Biology, 2003

656 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3718d17d95633500425e20cb2e41e12c8eeabdaf

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In Epidemiology

1. L. Galluzzi
2. Guido Kroemer
3. C. Brenner
4. Beth Levine
5. Douglas R. Green
6. V. Deretic
7. Alec C. Kimmelman
8. N. Mizushima

In Molecular Biology

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2. L. Galluzzi
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4. Simon Cook
5. H. Llewelyn Roderick
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8. R. Rizzuto

Citations in the corpus

• Flavonoids in Cancer and Apoptosis (2018, background): “Cytochrome c factors in the release of Ca2+ ions through the activation of Inositol 1,4,5 phosphate on the surface of the ER to mitochondria resulting in accumulation of Ca2+ in mitochondrial space, hence increasing mitochondrial stress and pore formation [14,17].”
• Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival (2008, background): “Indeed, [Ca 2+ ] i increases have been observed during apoptotic cell deat”
• Calcium, ATP, and ROS: a mitochondrial love-hate triangle. (2004, background): “In addition, recent evidence has suggested that cytochrome c can bind to the endoplasmic reticulum (ER) inositol 1,4,5trisphosphate receptor (IP3R), rendering the channel insensitive to autoinhibition by high [Ca(2) ]c and resulting in enhanced ER Ca(2) release (14, 15).”
• Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis. (2006, background): “Boehning and co-workers showed high affinity binding of cytochrome c to the IP3Rs, which blocks the Ca2+-dependent inhibition of the IP3-induced Ca2+ efflux [22].”
• Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis (2008, background): “, 1996), but subsequent studies have shown that the type 1 isoform can also mediate apoptosis (Hirota et al., 1999; Boehning et al., 2003; Assefa et al., 2004).”
• Mitochondrial membrane permeabilization in cell death. (2007, background): “Upon release, a fraction of Cyt c is also targeted to the ER membrane, where it binds to type I IP3R to amplify Ca(2) -dependent MMP-mediated apoptosis (61, 62).”