Disruption of the Epithelial Apical-Junctional Complex by Helicobacter pylori CagA

By M. Amieva, R. Vogelmann, A. Covacci, L. Tompkins, James Nelson, Stanley Falkow. Science, 2003

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Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk (2010, background): “pylori preferentially adheres to gastric epithelial cells in close proximity to tight junctions (13, 129) and can alter localization of the component proteins that constitute apicaljunctional complexes (13, 93, 164, 345).”
Intestinal permeability – a new target for disease prevention and therapy (2014, background): “EspM Activation of RhoA and TJ disruption RhoA [70-72]”
The tight junction: a multifunctional complex. (2004, background): “Subsequent to this interaction, TJ barrier function is disrupted and cell shape is significantly altered (3).”
A Transgenic Drosophila Model Demonstrates That the Helicobacter pylori CagA Protein Functions as a Eukaryotic Gab Adaptor (2008, neutral): “In retina expressing CagA, the normal cell shapes and neighbor relationships were perturbed (Figure 1E), similar to CagA-dependent epithelial disorganization observed in mammalian tissue culture monolayers [29,30].”
Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. (2004, background): “In this way, CagA induces TJ disassembly, which in turn facilitates bacterial attachment and eventually disruption of the epithelial barrier (2).”