Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

By V. Kagan, V. Tyurin, Jianfei Jiang, Y. Tyurina, V. Ritov, A. Amoscato, A. Osipov, N. Belikova, A. Kapralov, V. Kini and 7 more. Nature Chemical Biology, 2005

1,237 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c0e137f1f7e5663af4bc4f531aaef1629cbc2cf6

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Citations in the corpus

• Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine (2018, background): “This work (25) was among the first to reveal that cytochrome c could elicit a peroxidase-like activity in the presence of H2O2, a process later revealed to have profound consequences in mitochondria and cell redox biology (26).”
• Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer (2016, background): “First, as a central component of the apoptosome, and second, to concomitantly catalyze the oxidation of PS to provide an eat-me assurance signal for efferocytosis.(36) As discussed below, one of the most important future goals will be to assess whether all forms of externalized PS are immunosuppress”
• Mitochondria, oxidative stress and cell death (2007, background): “Selective peroxidation of cardiolipin was recently demonstrated by Kagan and colleagues to precede cytochrome c release during apoptosis [45] (Fig.”
• Redox Regulation of Cell Survival (2008, neutral): “cytochrome c, leading to cardiolipin peroxidation (142).”
• Molecular Mechanisms of Ischemia-Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation (2012, background): “Upon peroxidation, cardiolipin undergoes redistribution to the outer mitochondrial membrane [114] where it is required for release of apoptotic proteins from mitochondria into the cytosol [115].”
• The changing faces of glutathione, a cellular protagonist. (2003, background): “Cardiolipin can be oxidized by ROS or by the cardiolipin–cytochrome c complex (Kagan et al., 2005).”
• REACTIVE OXYGEN SPECIES, CELLULAR REDOX SYSTEMS AND APOPTOSIS (2010, neutral): “At low mitochondrial ROS, tightly bound cytochrome c exhibits increased peroxidase activity [192] that oxidizes cardiolipin and facilitates its detachment [193,194].”
• Mitochondrial Glutathione, a Key Survival Antioxidant (2009, background): “Cytochrome c is normally bound to the MIM by association with cardiolipin, and it has been postulated that cardiolipin loss or peroxidation lessens the binding of cytochrome c to the MIM, favoring the permeabilization of isolated liver mitochondria and release of cytochrome c (66, 111).”
• Mitochondrial membrane permeabilization in cell death. (2007, background): “Upon MMP-related apoptosis induction, Cyt c acts as a cardiolipin oxygenase, thus contributing via cardiolipin oxidation to both its own release and to that of additional proapoptotic factors (359).”
• Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects. (2007, background): “Studies of oxidativemodification of cytochrome c by H2O2 in cell-free systems have identified tyrosyl radicals [103,104] and dityrosine formation [105], indicators of electron transfer from an oxo-ferryl heme species similar to peroxidase Compound I [99]; in cells, cardiolipin is involved in control”
• Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation (2013, background): “…Apaf-1 (Garrido et al., 2006; Immunity 39, 1–13, August 22, 2013 ª2013 Elsevier Inc. 9 (legend continued on next page) Nlrp3 Inflammasome Activation through Cardiolipin 10 Immunity 39, 1–13, August 22, 2013 ª2013 Elsevier Inc. Nlrp3 Inflammasome Activation through Cardiolipin Kagan et al., 2005).”
• Cytochrome c: functions beyond respiration (2008, background): “Cardiolipin can be oxidized by phospholipase A 2 , by reactive oxygen species (ROS) or by the cardiolipin–cytochrome c comple”