Dissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1

By Paul E. Gilbert, R. Kesner, Inah Lee. 2001

691 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

Generalization Through the Recurrent Interaction of Episodic Memories (2012, background): “…the DG is functionally relevant, with deficits in this process leading to an impaired ability to discriminate between similar stimuli or environments (Clelland et al., 2009; Deng et al., 2010; Gilbert et al., 2001; Hunsaker, Rosenberg, & Kesner, 2008; McHugh et al., 2007; Nakashiba et al., 2012).”
Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “For example, lesion and genetic deletion studies have shown that the dentate gyrus is necessary for the discrimination of similar contexts (Gilbert et al., 2001; McHugh et al., 2007; Hunsaker et al., 2008).”
Environmental enrichment and neurogenesis: from mice to humans (2015, background): “Lesion of the DG (but not CA1) in rats specifically interfered with spatial pattern separation when choosing between two similar spatial locations [44].”
Differential contributions of dorsal hippocampal subregions to memory acquisition and retrieval in contextual fear‐conditioning (2004, methodology): “Since neither CA1- nor CA3-unique neurotoxins are currently available, we have developed injection parameters suitable to induce subregion-specific lesions with ibotenic acid, which has produced fairly selective damage in either CA1 (Gilbert et al., 2001) or CA3 (see below).”
Physiological properties and behavioral correlates of hippocampal granule cells and mossy cells (2017, positive): “In support of this hypothesis, damage to the dentate gyrus diminishes the animals’ ability to distinguish between similar environmental contexts, supporting its role in pattern separation (Gilbert et al., 2001; McHugh et al., 2007; Hunsaker et al., 2008; Kim and Lee, 2011; Nakashiba et al., 2012).”
Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation (2011, methodology): “…as a function of the extent of input pattern differences such as by varying the distance of spatial location systematically in the cheeseboard spatial discrimination task (Gilbert et al., 2001), further supporting a relationship between the pattern separation ability and behavioral outcome.”
The mechanisms for pattern completion and pattern separation in the hippocampus (2013, result): “…2006; Rolls et al., 2006), enabling the hippocampus to store different memories of even similar events, and this prediction has been confirmed (Gilbert et al., 2001; Rolls and Kesner, 2006; Leutgeb and Leutgeb, 2007; McHugh et al., 2007; Goodrich-Hunsaker et al., 2008; Rolls, 2008; Kesner et…”
Pattern separation: a common function for new neurons in hippocampus and olfactory bulb (2011, positive): “Experimental evidence for a role of the DG in pattern separation first came from lesion studies in rodents showing that ablation of the DG impaired discrimination of two spatial locations based on distal environmental cues (Gilbert et al., 2001).”
Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain (2009, methodology): “…formation, the DG has recently been proposed to perform a pattern separation role by sparsifying and orthogonizing inputs into the hippocampus in both rodent models and human subjects (Gilbert et al., 2001; Rolls and Kesner, 2006; Leutgeb et al., 2007; McHugh et al., 2007; Bakker et al., 2008).”
Using immediate-early genes to map hippocampal subregional functions. (2007, background): “Accordingly, rats with selective lesion of the CA3 showed impairment in spatial pattern completion in a delayed matching-to-place task (Gold and Kesner 2005).”
A Role for Hilar Cells in Pattern Separation in the Dentate Gyrus: A Computational Approach (2009, background): “…is most critical when the organism must discriminate between highly overlapping inputs, but less critical when the inputs are readily distinguished (Gilbert et al., 2001), and the finding that population correlations in dentate granule cells are reduced more for extremely similar inputs than for…”
Pattern Separation in the Dentate Gyrus: A Role for the CA3 Backprojection (2010, background): “…recent empirical data regarding selective DG manipulations support the idea that the DG is involved in pattern separation, particularly in tasks that require very similar stimuli to be distinguished (Gilbert et al., 2001; McHugh et al., 2007; Hunsaker et al., 2008; Clelland et al., 2009).”