Physiological properties and behavioral correlates of hippocampal granule cells and mossy cells

By Y. Senzai, György Buzsáki. 2017

302 citations recorded by the source corpus.

Summary The hippocampal dentate gyrus is often viewed as a segregator of upstream information. Physiological support for such function has been hampered by a lack of well-defined characteristics that can identify granule cells and mossy cells. We developed an electrophysiology-based classification of dentate granule cells and mossy cells in mice that we validated by optogenetic tagging of mossy cells. Granule cells exhibited sparse firing, had a single place field, and showed only modest changes when the mouse was tested in different mazes in the same room. In contrast, mossy cells were more active, had multiple place fields and showed stronger remapping of place fields under the same conditions. Although granule cell-mossy cell synapse was strong and facilitating, mossy cells rarely ‘inherited’ place fields from single granule cells. Our findings suggest that the granule cells and mossy cells could be modulated separately and their joint action may be critical for pattern separation.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, neutral): “Recently, three studies addressed these limitations by developing classification methods for electrophysiological recordings (GoodSmith et al., 2017; Senzai and Buzsáki, 2017) or using calcium imaging (Danielson et al.”
Pattern separation in the hippocampus through the eyes of computational modeling (2017, background): “…this role (Treves, Tashiro, Witter, & Moser, 2008) due to their activity sparseness (Danielson et al., 2017; GoodSmith et al., 2017; Schmidt et al., 2012), low firing rate (Danielson et al., 2016; Senzai & Buzs (cid:1) aki, 2017) and sparse connectivity (Amaral, Scharf-man, & Lavenex, 2007).”
Spatial representations of granule cells and mossy cells of the dentate gyrus (2017, methodology): “The classification techniques described here and in Senzai and Buzsáki (2017) will allow future studies to identify, with a high degree of confidence, the different cell types recorded in the DG/ CA3c region and will supply much more reliable and consistent data on the functional properties of…”