Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

By R. Kayed, E. Head, J. L. Thompson, Theresa M. McIntire, S. Milton, C. Cotman, C. Glabe. Science, 2003

4,109 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/c0b3e68c9f7c224fd5a80a2c65fd6dee1f023144

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Citations in the corpus

Islet amyloid polypeptide, islet amyloid, and diabetes mellitus. (2011, background): “Oligomerspecific antibodies that are said to recognize common structures independently of the amyloid protein have been produced (180).”
Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. (2012, background): “, dimers, trimers, tetramers, dodecamers, higher oligomers) in synthetic Ab peptide preparations (Lambert et al. 1998; Bitan et al. 2001; Kayed et al. 2003), in cell culture media (Podlisny et al.”
The Essential Medicinal Chemistry of Curcumin (2017, neutral): “136 However, the extremely long incubation times reported here would require follow-up to exclude the likely possibility of aggregation or degradation in the assay conditions.”
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. (2006, methodology): “Ten mg of nuclear and mitochondrial protein lysates were loaded from the cell-lines, and immunoblotting analysis was carried out using an A11 antibody ( 36 ) specific for oligomer Ab. Oligomers were found mainly in the mitochondrial pellet of the mutant human APP cell line, not in that of the WT hum”
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism (2013, neutral): “(2005) 3D structure of Alzheimer’s amyloid-beta(1-42) fibrils.”
Principles of protein folding, misfolding and aggregation. (2004, background): “The concept of a generic nature of such aggregates, and their effects on cells, has recently been reinforced through experiments with antibodies that cross-react with early aggregates of different peptides and proteins—and inhibit their toxicity [92].”
Molecular chaperones in protein folding and proteostasis (2011, background): “Notably, some common structural epitopes have been detected on the prefibrillar oligomers of different polypeptide”
What is the role of protein aggregation in neurodegeneration? (2005, background): “There seem to be structures that are shared by various aggregating protein”