Origin of new glial cells in intact and injured adult spinal cord.

By F. Barnabé-Heider, C. Göritz, H. Sabelström, H. Takebayashi, F. Pfrieger, K. Meletis, J. Frisén. 2010

600 citations recorded by the source corpus.

Several distinct cell types in the adult central nervous system have been suggested to act as stem or progenitor cells generating new cells under physiological or pathological conditions. We have assessed the origin of new cells in the adult mouse spinal cord by genetic fate mapping. Oligodendrocyte progenitors self-renew, give rise to new mature oligodendrocytes, and constitute the dominating proliferating cell population in the intact adult spinal cord. In contrast, astrocytes and ependymal cells, which are restricted to limited self-duplication in the intact spinal cord, generate the largest number of cells after spinal cord injury. Only ependymal cells generate progeny of multiple fates, and neural stem cell activity in the intact and injured adult spinal cord is confined to this cell population. We provide an integrated view of how several distinct cell types contribute in complementary ways to cell maintenance and the reaction to injury.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetics

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Hongjun Song
2. Guo-li Ming
3. A. Tran
4. P. Warren
5. J. Silver
6. J. Frisén
7. Fred H. Gage
8. James Bradley Aimone

In Developmental Neuroscience

1. Hongjun Song
2. Guo-li Ming
3. J. Frisén
4. J. Silver
5. A. Tran
6. Fred H. Gage
7. R. Hen
8. James Bradley Aimone

In Genetics

1. Guo-li Ming
2. Hongjun Song
3. German Ignacio Parisi
4. Fred H. Gage

Citations in the corpus

• Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Notably, proliferating neural precursors are present in other CNS regions where they give rise to oligodendrocytes and astrocytes (Barnabé-Heider et al., 2010; Lie et al., 2002; Palmer et al., 1999).”
• The Biology of Regeneration Failure and Success After Spinal Cord Injury. (2018, background): “Genetic fate mapping further revealed that a small subset of ependymal cells differentiate into NG2 oligodendrocytes (21).”
• Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms (2019, background): “These cells can give rise to new scar forming astrocytes and OPCs (278) (279) (280) .”
• EphB signaling controls lineage plasticity of adult neural stem cell niche cells (2010, background): “Ependymal cells in the adult spinal cord are even more plastic and display neural stem cell properties (Barnabé-Heider et al., 2010; Meletis et al., 2008).”