New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

By Bryan A. Gibson, W. Kraus. Nature reviews. Molecular cell biology, 2012

1,154 citations recorded by the source corpus.

Subfields: Electrical and Electronic Engineering, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/c091363721e69708ed8f3a32e6235e32d3d77a49

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Electrical and Electronic Engineering

1. Jian Lei
2. Rolf Hilgenfeld
3. Y. Kusov
4. Rebecca Gupte
5. Ziying Liu
6. W. Kraus

In Immunology

1. Guido Kroemer
2. L. Galluzzi
3. Jian Lei
4. Rolf Hilgenfeld
5. Y. Kusov
6. W. Kraus
7. Douglas R. Green
8. L. Zitvogel

In Oncology

1. Guido Kroemer
2. L. Galluzzi
3. Johan Auwerx
4. Rebecca Gupte
5. Ziying Liu
6. Jian Lei
7. Rolf Hilgenfeld
8. Y. Kusov

Citations in the corpus

• Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein (2017, positive): “For example, PARP7 (ARTD14), PARP10 (ARTD10), PARP12 (ARTD12), and PARP14 (ARTD8) add mono-ADPr to other proteins and themselves (Bütepage et al., 2015), while PARP1 (ARTD1) and PARP2 (ARTD2) add poly(ADPr)s (Gibson and Kraus, 2012).”
• Wnt/β-catenin signaling in cancers and targeted therapies (2021, background): “Tankyrase1/2 is a poly (ADP-ribose) polymerase (PARP), attaching PAR chains onto substrates by its catalytic action.(172,173) The enzymes bind and then PARylate Axins, utterly, the Axins are ubiquitylated and degraded.”
• NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, background): “stress, and metabolism, among other cellular pathways (reviewed in Cantó et al., 2013; Gibson and Kraus, 2012; Kraus and Hottiger, 2013).”
• PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes (2017, background): “…(PTM) of proteins resulting in the covalent attachment of a single ADP-ribose unit [i.e., mono(ADP-ribose) (MAR)] or polymers of ADP-ribose units [i.e., poly(ADP-ribose) (PAR)] on a variety of amino acid residues on target proteins (Gibson and Kraus 2012; Daniels et al. 2015a).”
• Metabolic control of cell death (2014, background): “Poly(ADP-ribose) polymerases (PARPs) make up a large family of enzymes that catalyze the addition of poly(ADP-ribose)moieties (an NADdependent reaction also known as ADP ribosylation) to multiple substrates, hence regulating a plethora of cellular processes, notably the repair of single and double-s”
• Systems biology of cisplatin resistance: past, present and future (2014, background): “to influence the sensitivity of pancreatic and ovarian neoplasms to inhibitors of poly(ADP-ribose) polymerase 1 (PARP1), another important regulator of DNA repair.(144)”
• The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling (2013, neutral): “…polymer- ase proteins—with PARP1 and PARP2 representing the main PARP activities in mammals—were classically described as DNA repair proteins (Gibson and Kraus, 2012; Schreiber et al., 2006), but recent studies have linked these proteins to metabolism (Asher et al., 2010; Bai et al.,…”