Vascularized and functional human liver from an iPSC-derived organ bud transplant

By T. Takebe, K. Sekine, M. Enomura, H. Koike, M. Kimura, Takunori Ogaeri, Ran-ran Zhang, Y. Ueno, Yun-Wen Zheng, N. Koike and 3 more. Nature, 2013

1,987 citations recorded by the source corpus.

Subfields: Hepatology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/956a7e3e71548f39ac4ffe8e3fddd0d6a498f2d4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hepatology

1. Hans Clevers

In Molecular Biology

1. Hans Clevers
2. Juergen A. Knoblich
3. James M. Wells
4. Shu Chien
5. Robert Langer
6. Madeline A. Lancaster
7. R. Nusse
8. Sigrid A. Langhans

In Surgery

1. Hans Clevers
2. J. Lewis
3. Mark A. Skylar-Scott
4. Robert Langer
5. Shu Chien
6. J. Karp
7. V. Mohanraj
8. Y. Chen

Citations in the corpus

• Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels (2019, background): “This constraint arises due to the delay between implantation and anastomosis with host vasculature, which necessitates a reliance on the diffusive transport of oxygen and nutrients to maintain cell viability (2, 8, 9).”
• Modeling Development and Disease with Organoids. (2016, background): “Plated at high density on a layer of Matrigel, 3D aggregates spontaneously formed (Takebe et al., 2013).”
• Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting (2016, methodology): “, HPCs and HLCs, respectively, have demonstrated their potentials in organizing into vascularized liver buds (11, 13) and in the construction of in vitro models with simple geometry (10, 12, 14).”
• Stem Cell Organoid Engineering (2016, positive): “, 2011), liver (Takebe et al., 2013), and kidney (Takasato et al.”
• Organogenesis in a dish: Modeling development and disease using organoid technologies (2014, background): “Human liver buds have already been shown to produce human-specific metabolites (41), which suggests that liver organoids could represent an ideal system to perform these types of studies.”
• In vitro generation of human pluripotent stem cell derived lung organoids (2015, background): “Several recent advances in generating 3-dimensional (3D) organ-like tissues, called ‘organoids’, have been reported (Meyer et al., 2011; Spence et al., 2011; Nakano et al., 2012; Takebe et al., 2013; Lancaster et al., 2013; McCracken et al., 2014).”