Organogenesis in a dish: Modeling development and disease using organoid technologies

By Madeline A. Lancaster, Juergen A. Knoblich. Science, 2014

2,625 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/8ad7fb843be6dc599af50d98292f6f2f298eec3a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Yong Teng
2. Caleb Jensen
3. Robert Langer
4. Sigrid A. Langhans
5. Hans Clevers
6. William L. Murphy
7. Ali Khademhosseini
8. V. Mohanraj

In Molecular Biology

1. Sigrid A. Langhans
2. Robert Langer
3. Ron M. Stewart
4. Hans Clevers
5. R. Nusse
6. Elaine Fuchs
7. C. Blanpain
8. O. Farokhzad

In Surgery

1. Yong Teng
2. Caleb Jensen
3. Robert Langer
4. Sigrid A. Langhans
5. Hans Clevers
6. J. Karp
7. V. Mohanraj
8. Y. Chen

Citations in the corpus

• Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “While research into new 3D culture technologies that take into account the functional unit of tissues such as organoids has gained great momentum (Lancaster and Knoblich, 2014; Shamir and Ewald, 2014; Clevers, 2016; Kretzschmar and Clevers, 2016; Simian and Bissell, 2017), much work remains to be do”
• Brain Region-specific Organoids using Mini-bioreactors for Modeling ZIKV Exposure (2016, neutral): “Structures resembling whole developing organs, named organoids, have recently been generated via 3D cultures and include intestinal, kidney, retinal, and cerebral organoids (Lancaster and Knoblich, 2014; Yin et al., 2016).”
• Human pluripotent stem cell-derived neural constructs for predicting neural toxicity (2015, background): “Matrigel is widely used as a scaffold for organoid culture (53), but varies between batches and is a poorly defined mixture of proteins, including many potent growth factors and extracellular matrix components (54).”
• Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3 (2016, neutral): “More recently, stem cells and iPSCs have been differentiated into 3D organoid systems to study the development of the intestine, retina, liver, kidney, and even the brain (Koehler and Hashino, 2014; Lancaster and Knoblich, 2014).”
• Stem Cell Organoid Engineering (2016, positive): “The recent availability of stem cell-derived organoid systems to provide 3D self-organized tissue models provides a compelling new class of biological model to serve as both tissue and organ proxies (Lancaster and Knoblich, 2014).”
• Modeling Development and Disease with Organoids. (2016, background): “…self-renewing progenitors and differentiated cell types, such as neurons and intermediate progenitors, that migrate outward to generate region-specific stratified structures such as the medulla, the optic tectum, and the cerebral cortex (see Eiraku and Sasai, 2012; Lancaster and Knoblich, 2014).”
• Is It Time to Start Transitioning From 2D to 3D Cell Culture? (2020, background): “Lastly, the difference in shape between 2D and 3D cells causes a difference in local pH levels within the cells as a result of 3D cells having greater depth than 2D cells (Lancaster and Knoblich, 2014).”