Early experience and serotonin transporter gene variation interact to influence primate CNS function

By A. Bennett, Klaus-Peter Lesch, A. Heils, J. Long, J. Lorenz, S. Shoaf, M. Champoux, S. Suomi, M. Linnoila, J. Higley. Molecular Psychiatry, 2002

622 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bfd648bfae6f78bc4eea8020dee0d82ca91fde72

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Citations in the corpus

Temperament, Attention, and the Development of Self‐Regulation (2008, background): “…studies, the effect of specific genes depended on peer versus mother rearing, with a short allele of the 5-HTTLR gene linked to lower orientation scores, but only for monkeys who had been nursing monkeys reared with peers, not for mother reared monkeys (Barr et al., in press; Bennett et al., 2002).”
Gene-environment interplay and psychopathology: multiple varieties but real effects. (2006, background): “…too, have shown that the same short allele was associated with a differential response to adverse rearing as shown by serotonin metabolites in the cerebral spinal fluid (Bennett et al., 2002), by visual orientation to stimuli (Champoux et al., 2002) and by increased ACTH levels (Barr et al., 2004).”
Strategy for investigating interactions between measured genes and measured environments. (2005, background): “To date, most evidence of connections between genes and pathogen responsiveness emerges from studies of rodents and nonhuman primates having known humanrelevant genotypes.(91,93,94) As yet, there is relatively little information about genes associated with environmental pathogen responsiveness among”
Insights for Behavioral Ecology from Behavioral Syndromes. (2008, background): “…or in addition, perhaps a female’s maternal style is part of her overall behavioral type; perhaps mothers that engage in more abusive behavior as parents are also distinctive in other respects, which outweigh the costs of impaired maternal performance (Bennett et al., 2002; Champoux et al., 2002).”
Social Exchange and Micro Social Order (2008, background): “2004b), lower visual orientation scores assessed on days 7, 14, 21, and 30 of life (Bennett et al. 2002), and an increased level of alcohol consumption among females (Barr et al.”
Epigenetics and the biological definition of gene x environment interactions. (2010, background): “Monkeys bearing the S version of the 5-HTTP promoter polymorphism show reduced 5-HT activity, increased impulsivity, and are more aggressive than animals bearing the longer version of the promoter variant (Bennett et al., 2002; Champoux et al., 2002).”
Resilience as a dynamic concept (2012, background): “Two examples of experimental studies may be given: one in rhesus monkeys focusing on central serotonin functioning (Bennett et al., 2002) and one in humans, using brain imaging to examine the neural effects of G E (Hariri et al., 2002; see also Hariri, 2011).”
Gene–environment interaction analysis of serotonin system markers with adolescent depression (2004, background): “46 and an interaction between 5HTTLPR , stressful-rearing conditions and decreased serotonergic function in rhesus monkeys”
The enduring effects of abuse and related adverse experiences in childhood (2006, background): “Alterations in serotonergic (Rosenblum 1994; Bennett 2002) and GABAergic (Caldji 2000) receptors also contribute to deficits in social attachment and regulation of mood and affect following early stress.”
Coping resources, coping processes, and mental health. (2007, neutral): “387 NEURAL LINKS FROM COPING TO STRESS-RELATED MENTAL AND PHYSICAL HEALTH OUTCOMES . . . . . . . . . 388 Neural Bases of Threat Detection and Coping . . . . . . . . . . . . . . . . . . . 388 PATHWAYS FOR INTERVENTION . . . . . . . . . . . . . . 390 Interventions Directed Toward Coping Resources . .…”