Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

By Laure Crabbe, R. Verdun, C. Haggblom, J. Karlseder. Science, 2004

616 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Plant Science

View Paper: https://www.semanticscholar.org/paper/bfa5cce0f88b132c98287a9d0e9ae19b4c2a88e4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Wilhelm Palm
2. T. de Lange
3. D. Rhodes
4. R. Reddel
5. Anthony J. Cesare
6. Peter M. Lansdorp
7. G. Aubert
8. H. Lipps

In Physiology

1. Wilhelm Palm
2. T. de Lange
3. R. Reddel
4. Anthony J. Cesare
5. Peter M. Lansdorp
6. G. Aubert
7. H. Lipps
8. D. Rhodes

In Plant Science

1. Howard Y. Chang
2. T. de Lange

Citations in the corpus

• SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin (2008, positive): “4d–f), defects observed in WS cells and associated with aberrant telomere processing during replication 8,13,20 .”
• How shelterin protects mammalian telomeres. (2008, background): “They are ubiquitously expressed, and although one report found a reduction of the telomeric TRF1 in S phase (191), another similar study showed no cell cycle variation (41).”
• G-quadruplexes and their regulatory roles in biology (2015, background): “The WRN helicase is necessary for preventing dramatic telomere loss during lagging strand replication of the G-rich strand and the consequent accumulation of chromosome aberrations such as chromosome fusions (85).”
• Shelterin: the protein complex that shapes and safeguards human telomeres. (2005, positive): “Examples of non-shelterin proteins at human telomeres Protein complex Nontelomeric function Effects at telomeres Interactions Mre11/Rad50/Nbs1 recombinational repair DNA damage sensor t-loop formation/resolution? required for t-loop HR associated with shelterin ERCC1/XPF NER, crosslink repair 3 flap”
• Telomeres and aging. (2008, background): “Recently, two other mechanisms of telomere shortening were proposed: the failure to unwind or correctly process higher order structures of G-rich telomeric DNA (51, 62) and the deletion of T-loops by homologous recombination (223).”
• Alternative lengthening of telomeres: models, mechanisms and implications (2010, background): “Telomere loss due to failure of normal DNA replication has been best described in primary human cells deficient for the Werner syndrome RecQ helicase (WRN) or the nuclease FEN1 (Ref”