Alternative lengthening of telomeres: models, mechanisms and implications

By Anthony J. Cesare, R. Reddel. Nature reviews genetics, 2010

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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal (2013, background): “At the genetic level, the most characteristic change is a t(12;16) (q13;p11) chromosomal translocation that results in the fusion of the FUS and DDIT3 genes (16, 17).”