Genomic DNA methylation: the mark and its mediators.

By R. Klose, A. Bird. 2006

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In Molecular Biology

Citations in the corpus

Impact of cytosine methylation on DNA binding specificities of human transcription factors (2017, background): “In addition, mCpG dinucleotides can be recognized by a specific class of proteins, the methyl-CpG domain–binding proteins, some of which can recruit histone deacetylases and are thought to promote local chromatin condensation (7, 13).”
Epigenetic Gene Regulation in the Bacterial World (2006, background): “In turn, methyl-CpG binding proteins affect the transcription state of a local DNA region through further interaction with chromatin-remodeling proteins (145).”
Cancer epigenetics: from mechanism to therapy. (2012, background): “These in turn function to recruit histone-modifying enzymes to coordinate the chromatin-templated processes (Klose and Bird, 2006).”
The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing (2010, background): “Changes in DNA methylation status are associated with X-inactivation, imprinting, and the development of primordial germ cells [2–5]; moreover, DNA methylation is highly aberrant in cancer [6–9].”
Socioeconomic status and the brain: mechanistic insights from human and animal research (2010, background): “This mechanism involves DNA methylation, which affects chromatin structure and thereby regulates transcription factor binding and subsequently, gene transcriptio”
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage. (2010, background): “DNA modifications have been analyzed in considerable detail, and the characterization of (cytosine-5) DNA methylation has been crucial for understanding the molecular basis of epigenetic gene regulation (Klose and Bird 2006).”
Epigenetics and the biological definition of gene x environment interactions. (2010, background): “In this case, selected cytosines are methylated and the presence of the methyl group attracts a class of proteins know as methylated-DNA binding proteins (Klose & Bird, 2006).”
Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities (2018, background): “These include chemical modification of DNA bases [56, 57, 58], and of the histone proteins that package DNA [59, 60] into nucleosome structures.”
Transcriptional Regulation of the Human Tumor Suppressor DOK1 by E2F1 (2012, background): “DNA methylation is thought to silence gene expression either by directly impeding transcription factor binding or by recruiting other proteins, known as methyl-CpG-binding domain proteins (MBDs), histone deacetylases (HDACs), and other chromatin remodeling proteins (4, 13).”
Acute exercise remodels promoter methylation in human skeletal muscle. (2012, background): “Evidence is emerging that epigenetic modifications through DNA methylation contribute to the increased risk and development of metabolic disease by modifying the expression of genes controlling whole body energy and glucose homeostasis (Barrès et al., 2009; Klose and Bird, 2006).”
Epigenetics: Definition, Mechanisms and Clinical Perspective (2009, background): “De novo methyltransferases may be directly targeted to specific DNA sequences, may necessitate the interaction with other DNA binding proteins or may be guided by RNA interference (RNAi) in a process called RNA-directed DNA methylation (RdDM).(27) Besides covalent modifications of DNA, histones and ”
CpG islands and the regulation of transcription. (2011, neutral): “4B; for reviews, see Klose and Bird 2006; Bogdanovic and Veenstra 2009).”