Centrosome amplification drives chromosomal instability in breast tumor development

By W. Lingle, S. Barrett, V. Negron, Antonino B. D’Assoro, K. Boeneman, Wanguo Liu, C. Whitehead, C. Reynolds, J. Salisbury. Proceedings of the National Academy of Sciences of the United States of America, 2002

601 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Genetics

View Paper: https://www.semanticscholar.org/paper/bf0f60429e733ef065608046b71a82dcf7994e43

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Citations in the corpus

Cell death by mitotic catastrophe: a molecular definition (2004, background): “…and constitutes a negative prognostic factor, while aneuploidy is a near-to-general characteristic of cancer (Slovak et al., 2000; Choma et al., 2001; Jallepalli and Lengaue, 2001; Shih et al., 2001; Lingle et al., 2002; Masuda and Takahashi, 2002a, b; Sen et al., 2002; Tort et al., 2003).”
Centrioles, centrosomes, and cilia in health and disease. (2009, background): “In particular, many cancers display not only numerical but also structural centrosome aberrations, most commonly enlarged centrosomes and extracentriolar assemblies of PCM components (Lingle et al., 2002; Pihan et al., 1998).”
Centrosome aberrations: cause or consequence of cancer progression? (2002, background): “2 ), the formation of ACENTRIOLAR BODIES and alterations in the phosphorylation state of PCM component”
Network modeling links breast cancer susceptibility and centrosome dysfunction. (2007, background): “Notably, centrosome hypertrophy and amplification are often evident in early stage proliferative breast lesion”
Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis (2009, background): “Aneuploidy and chromosomal instability Some tumour cells are stably aneuploid, reflecting a transient chromosome missegregation event at some point in the development of the tumour that leads to a stably propagated and inherited abnormal karyotyp”
An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. (2006, background): “Studies of the cytogenetic evolution in breast cancer have suggested that a highly aneuploid state could originate from a polyploidization event concurrent with a gradual loss of individual chromosome copies ( 40 ).”
From polyploidy to aneuploidy, genome instability and cancer (2004, background): “One recent study, in which fluorescence in situ hybridization (FISH) was used to examine karyotypic changes in breast cancer, found that approximately half of the tumours had a stable karyotype and the rest showed cell-to-cell variation in karyotyp”