Centrosome aberrations: cause or consequence of cancer progression?
By Erich A. Nigg. Nature Reviews. Cancer, 2002
791 citations recorded by the source corpus.
Subfields: Accounting, Management, Monitoring, Policy and Law
View Paper: https://www.semanticscholar.org/paper/1f25f6e0bc1d1daa35d60b8010f190b4638aedd2
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Citations in the corpus
- On the road to cancer: aneuploidy and the mitotic checkpoint (2005, background): “It can also be caused by defects in duplication, maturation or segregation of centrosome”
- Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation (2007, neutral): “Mistaken centrosome replication is linked to oncogenesi”
- Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. (2008, background): “Thus, we speculate that the forces holding centrosomes together in cancer cells have much in common with the forces that bundle the minus ends of Kwon et al. 12 GENES & DEVELOPMENT MTs in acentrosomal spindles (Karsenti and Vernos 2001; Nigg 2002).”
- The Polo kinase Plk4 functions in centriole duplication (2005, neutral): “dtd" [ ]> The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in other eukaryotes have multiple, crucial roles in meiotic and mitotic cell divisio”
- From polyploidy to aneuploidy, genome instability and cancer (2004, background): “Supernumerary centrosomes can be clustered in a manner that enables the formation of a bipolar mitotic spindl”
- The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease (2007, background): “Centrosome duplication must be coupled to the events of the nuclear cell cycle and this strict coordination is regulated by multiple pathways involving Pro-directed phosphorylatio”
- Centrosome biogenesis and function: centrosomics brings new understanding (2007, background): “Abnormalities in the spindle-pole-organization function occur in many cancers and can be associated with genomic instabilit”
- Flies without centrioles. (2006, background): “Centrosome defects are believed to contribute to the genetic instability associated with many cancers (Nigg, 2002), and genetic studies have implicated centrosomes in microcephaly, a condition associated with a small brain size at birth (Woods et al., 2005).”
- Autophagy suppresses tumor progression by limiting chromosomal instability. (2007, background): “Abnormalities in the microtubule framework can arise due to abnormally large cell size, and, moreover, supernumerary centrosomes and large nuclei are defining traits of excess DNA content as well as genomic instability (Nigg 2002).”