Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes.

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ECOD: An Evolutionary Classification of Protein Domains (2014, background): “However, SCOP tends to be conservative in assessing evolutionary relationships, and many homologous links reported in literature are not currently reflected [6,7,8,9,10,11].”
HorA web server to infer homology between proteins using sequence and structural similarity (2009, result): “Rossmann-like folds in the a/b class (26)] may be homologous, the accuracies on ‘FD’ and ‘CL’ are not as informative as those on the other data sets.”
Neutron diffraction studies towards deciphering the protonation state of catalytic residues in the bacterial KDN9P phosphatase. (2013, background): “HADSF phosphatase biochemical functions have been invented and reinvented across these structural classes (Burroughs et al., 2006).”
Panoramic view of a superfamily of phosphatases through substrate profiling (2015, background): “S1) based on size, position of insert within the Rossmann fold, and overall topology (7).”