Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

By J. Cryan, Ted G. Dinan. Nature Reviews Neuroscience, 2012

4,134 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Gastroenterology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/be4d7a3306a36b4584064db14707ad3d2fd0cba8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. J. Foster
5. L. Rinaman
6. P. Kennedy
7. C. Stanton
8. S. Mazmanian

In Gastroenterology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. R. Stilling
5. P. Kennedy
6. J. Foster
7. Emeran A. Mayer
8. L. Rinaman

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. Patrice D Cani
5. F. Bäckhed
6. W. D. de Vos
7. S. Mazmanian
8. C. Stanton

Citations in the corpus

• Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, background): “…ranging from basic microbiology to translational applications (e.g. see Bercik et al. 2012; Berer & Krishnamoorthy 2012; Collins et al. 2012b, 2013; Cryan & Dinan 2012; Cryan & O’Mahony 2011; Forsythe & Kunze 2013; Lyte 2011, 2013; Nicholson et al. 2012; Rhee et al. 2009; Sommer & Bäckhed 2013).”
• Altered fecal microbiota composition in patients with major depressive disorder. (2015, background): “…in central nervous system function, namely through inflammation, and the hypothalamic–pituitary–adrenal (HPA) axis, and by affecting neurotransmission (Bangsgaard Bendtsen et al., 2012; Collins et al., 2012; Cryan and Dinan, 2012; Dinan and Cryan, 2013; Dinan et al., 2013; Wang and Kasper, 2014).”
• Gut microbiota are related to Parkinson's disease and clinical phenotype (2015, background): “Further possible mechanisms for microbiome–host interactions in PD could involve neurotoxins, neurotrophic factors, and neurotransmitters.(26,29,30,78,79) However, the relevance of the above-mentioned pathways with regard to PD remains unclear.”
• The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis (2018, neutral): “…the VN and/or spinal cord, endocrine (through the hypothalamic pituitary adrenal, HPA, axis), immune (cytokines), andmetabolic [short chain fatty acids, (SCFAs), tryptophan. . . ] (Cryan and Dinan, 2012; Brookes et al., 2013; Perez-Burgos et al., 2015; Forsythe et al., 2016; Sarkar et al., 2016).”
• Animals in a bacterial world, a new imperative for the life sciences (2013, background): “…(49), postembryonic maturation and renewal of epithelia in invertebrates and vertebrates (50 – 53), development and speci fi cation of the gut-associated lymphoid tissues in vertebrates (54), activation of the immune system in tsetse fl ies (55), and normal brain development in mammals (56, 57).”
• Cognitive Impairment by Antibiotic-Induced Gut Dysbiosis: Analysis of Gut Microbiota-Brain Communication (2016, background): “Abbreviations: ANOVA, analysis of variance; AUC, area under the curve; BDNF, brain-derived neurotrophic factor; BM, Barnes maze; CCL2, chemokine (C-C motif) ligand 2; CLDN5, claudin 5; GF, germ-free; GRIN2B, glutamate receptor, ionotropic, NMDA2B (epsilon 2), N-methyl-D-aspartate receptor subunit…”
• The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis? (2016, background): “As such, central nervous system function and subsequently also human and animal behaviour is influenced by microbial presence, metabolism and activity (Collins et al., 2012; Cryan and Dinan, 2012; Mayer et al., 2014; Sampson and Mazmanian, 2015).”
• Gut Microbiota is Altered in Patients with Alzheimer’s Disease (2018, positive): “Changes in the composition of the gut microbiota could increase intestinal permeability and induce inflammation that has been proved to increase the risk of AD [17].”
• Kynurenine pathway metabolism and the microbiota‐gut‐brain axis (2017, background): “mitters (Cryan and Dinan, 2012), and, as will be the focus here, through modulating circulating tryptophan availability with im-”
• Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring (2016, positive): “Colonization of Germ-Free Mice with the Microbiota fromMRD, but NotMHFDMice, Reverses Their Deficient Social Behavior Studies on germ-free (GF) mice have shown that the intestinal microbiota can influence brain development and function (Cryan and Dinan, 2012).”