Gut Microbiota is Altered in Patients with Alzheimer’s Disease
By Z. Zhuang, Lin-Lin Shen, Wei-Wei Li, Xue Fu, Fan Zeng, L. Gui, Y. Lü, Min Cai, Chi Zhu, Ying Tan and 6 more. Journal of Alzheimer's Disease, 2018
705 citations recorded by the source corpus.
Previous studies suggest that gut microbiota is associated with neuropsychiatric disorders, such as Parkinson’s disease, amyotrophic lateral sclerosis, and depression. However, whether the composition and diversity of gut microbiota is altered in patients with Alzheimer’s disease (AD) remains largely unknown. In the present study, we collected fecal samples from 43 AD patients and 43 age- and gender-matched cognitively normal controls. 16S ribosomal RNA sequencing technique was used to analyze the microbiota composition in feces. The composition of gut microbiota was different between the two groups. Several bacteria taxa in AD patients were different from those in controls at taxonomic levels, such as Bacteroides, Actinobacteria, Ruminococcus, Lachnospiraceae, and Selenomonadales. Our findings suggest that gut microbiota is altered in AD patients and may be involved in the pathogenesis of AD.
Subfields: Molecular Biology, Pharmacology, Physiology
View Paper: https://www.semanticscholar.org/paper/0d77f6a86a79b9427114acef7bf159dbb7f10514
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Citations in the corpus
- Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020, background): “Abnormal gut microbiota has been reported in several AD mouse models [589, 590].”