Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
By D. Cuthbertson, Kenneth Smith, J. Babraj, G. Leese, T. Waddell, P. Atherton, H. Wackerhage, P. Taylor, M. Rennie. The FASEB Journal, 2005
1,254 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/be409a17979c4633ddfde90394743dbab8b1d729
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Citations in the corpus
- International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines (2021, neutral): “The blunted response to exercise and nutritional stimulation of muscle protein synthesis has been termed “anabolic resistance” (186, 187).”
- Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. (2009, background): “We hypothesized that mixed MPS would demonstrate a dose response to dietary protein after resistance exercise and that the maximal effective (ie, maximally stimulatory for MPS) dose would be similar to what has previously been reported to be maximal at rest (7).”
- The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans (2018, background): “younger individuals (Atherton et al., 2010a; Cuthbertson et al., 2005), and with exercise being able to extend the duration of this anabolic response (beyond 2-3 h) when performed alongside intake of dietary protein of free EAA mixtures (Cuthbertson et al.”
- Sarcopenia, Dynapenia, and the Impact of Advancing Age on Human Skeletal Muscle Size and Strength; a Quantitative Review (2012, background): “However in young men this rate more than doubles upon either feeding or exercise but in old men these responses are blunted (Cuthbertson et al., 2005; Kumar et al., 2009).”
- Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. (2012, background): “Because the muscle protein synthetic response to nutritional (42, 43) and/or exercise (44, 45) stimuli has been reported to be blunted in senescent muscle, it is of even greater importance to define dietary interventions that can augment the benefits of exercise training in the elderly population.”
- Scientific Opinion on Dietary Reference Values for protein. (2012, background): “bolus) may influence the efficiency of the anabolic protein response (Cuthbertson et al., 2005; Katsanos et al., 2005; Paddon-Jones et al., 2004; Paddon-Jones and Rasmussen, 2009; Symons et al., 2007).”
- Skeletal muscle performance and ageing (2017, neutral): “5-fold higher synthesis rates in the young.(52) In a more recent study, Wall et al.”
- Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle (2008, methodology): “2005) have been shown to increase mixed muscle protein synthesis for up to 2 and 4 days, respectively, after the last exercise session Feeding (Cuthbertson et al. 2005; Fujita et al. 2007b) and resistance exercise (Coffey et al.”
- International Society of Sports Nutrition Position Stand: protein and exercise (2017, result): “This study, and the results reported by others [149] have led to the suggestion that an approximate 10 g dose of EAAs might serve as an optimal dose to maximally stimulate MPS and that intact protein feedings of appropriate amounts (as opposed to free amino acids) to elderly individuals may stimulat”