The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans

By D. Wilkinson, M. Piasecki, P. Atherton. Ageing Research Reviews, 2018

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Highlights • Loss of muscle mass with age is due to atrophy and loss of individual muscle fibres.• Anabolic resistance is fundamental in age-related fibre atrophy.• Fibre loss is associated with denervation and remodelling of motor units.• The plasticity of both factors should be considered in future research.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/baa56a38a5b6dbbe71b6240998af93b712d29072