Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans

By P. Baumann, T. Cech. Science, 2001

1,079 citations recorded by the source corpus.

Subfields: Ecology, Physiology, Plant Science

View Paper: https://www.semanticscholar.org/paper/bdf71cabf4a4b79f9b7ac1f353e5c7fdb21a4af6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology

1. M. Blasco
2. de Lange
3. T. de Lange

In Physiology

1. T. de Lange
2. M. Blasco
3. J. Karlseder
4. Wilhelm Palm
5. de Lange
6. Roderick J. O’Sullivan
7. R. Reddel
8. J. Shay

In Plant Science

1. T. de Lange
2. J. Karlseder
3. de Lange
4. M. Blasco
5. Dinshaw J. Patel

Citations in the corpus

• How shelterin solves the telomere end-protection problem. (2010, background): “The complex contains a third DNAbinding protein, POT1, that has two oligosaccharide/ oligonucleotide binding (OB) folds that associate with single-strand TTAGGG repeats (Baumann and Cech 2001; Loayza and de Lange 2003; Lei et al. 2004).”
• Alternative lengthening of telomeres in mammalian cells (2002, background): “It has been suggested that replication is normally inhibited by the telomeric DNA end binding protein, POT1 (Baumann and Cech, 2001).”
• How shelterin protects mammalian telomeres. (2008, background): “Like TEBPα, POT1 contains two OB folds in its N terminus with which it can recognize the G-strand telomeric sequence in vitro (9, 96, 107, 123).”
• Telomeres: protecting chromosomes against genome instability (2010, background): “POT1, although strongly implicated in telomere protection in yeas”
• Protection of mammalian telomeres (2002, background): “A candidate telomere end binding factor, Pot1, was recently identi®ed in the database based on homology to a similar protein from the ciliate Oxytricha nova (Baumann and Cech, 2001).”
• Human telomere, oncogenic promoter and 5′-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics (2007, background): “On the other hand, binding of POT1, a protein conserved from fission yeast to humans (51), disrupts G-quadruplex formation at telomeric G-rich overhangs (52), thereby promoting telomere extension by telomerase (53).”
• Human Telomerase and Its Regulation (2002, background): “The only single-stranded human telomere binding protein identified to date is POT1 (13), but its effects on human telomere length regulation have not yet been described.”
• Shelterin: the protein complex that shapes and safeguards human telomeres. (2005, positive): “The most conserved component of shelterin, POT1, was identified based on sequence homology to telomere end-binding factors in unicellular eukaryotes (Baumann and Cech 2001).”
• The epigenetic regulation of mammalian telomeres (2007, background): “, whereas a protein known as Pot1 (protection of telomeres 1) binds and protects the G-strand overhan”