Protection of mammalian telomeres

By T. de Lange. Oncogene, 2002

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. (2005, background): “Intriguingly, significant telomeric sequence was observed at sites of chromosomal fusions, potentially implicating other mechanisms such as those involved in uncapping telomeres or otherwise disrupting telomere integrity (de Lange, 2002; Smogorzewska et al., 2002).”
Human Telomerase and Its Regulation (2002, background): “In the past few years, an increasing number of telomere-associated proteins and their interacting partners have been identified (46, 63, 192).”