HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein.

By A. Orvedahl, D. Alexander, Z. Tallóczy, Qihua Sun, Yongjie Wei, Wei Zhang, D. Burns, D. Leib, Beth Levine. Cell Host and Microbe, 2007

855 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Parasitology

View Paper: https://www.semanticscholar.org/paper/bdcbfb9b0fe3c5df5dbaa69c28c698727558dfb9

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Citations in the corpus

Oncolytic viruses: a new class of immunotherapy drugs (2015, background): “Toxicity is mediated by the viral gene product ICP34.5, which counteracts the type I IFN response and antagonizes the PKR signalling pathway within non-dividing cells 56, [70] [71] [72] [73] .”
Eaten alive: a history of macroautophagy (2010, background): “, whereas autophagy inhibition is essential for viruses to evade innate immunity and cause diseas”
PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “A diverse array of pathogens interact with components of the autophagic pathway including Brucellus abortus (80, 81), Coxiella burnetii (82), Porphyromonas gingivalis (83), Salmonella enterica (84), Chlamydia trachomatis (85), Listeria monocytogenes (86), Group A Streptococcus (87, 88), Mycobacteriu”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “5 protein inhibits autophagy by targeting BECN1.(892)”
African Swine Fever Virus: A Review (2017, background): “5 protein, which inhibits autophagy by targeting Beclin1 [64].”
Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “5 protein inhibits autophagy by targeting BECN1.(580) While the impact of ICP34.”
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “…the need to limit IFN induction by this 18 Journal of General Virology 89 Downloaded from www.microbiologyresearch.org by IP: 54.70.40.11 On: Thu, 06 Dec 2018 10:52:31 pathway may also partially explain why HSV-1 has evolved a mechanism to block autophagy specifically (Orvedahl et al., 2007).”
Molecular definitions of autophagy and related processes (2017, neutral): “In line with this notion, several defects in the molecular machinery for macroautophagy — such as the genetic inhibition of Atg5 in mice — render animals more susceptible to succumb to infection (Orvedahl et al , 2010).”
Autophagy during viral infection — a double-edged sword (2018, background): “For example, in neurons, autophagy is involved in HSV-1 replication and reactivation of latent infection 128 .”