Adhesion-dependent cell mechanosensitivity.

By A. Bershadsky, Nathalie Q. Balaban, Benjamin Geiger. Annual Review of Cell and Developmental Biology, 2003

896 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/bdb638570c281b176e4639877d03b8010da18d28

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Citations in the corpus

Mechanics, malignancy, and metastasis: The force journey of a tumor cell (2009, background): “The integrated mechanics and dynamics of these systems enable cells to control their shape, generate force, and ultimately remodel the ECM [4–8].”
Assembly of Fibronectin Extracellular Matrix (2010, background): “…and cellECM interactions has grown significantly with the identification of ECM protein receptors, new ECM components, signal transduction downstream of ECM, and mechanical properties of ECM (see, for example, Aszódi et al. 2006, Bershadsky et al. 2003, Hynes 1990, Schwartz et al. 1995).”
Mechanical compression drives cancer cells toward invasive phenotype (2011, background): “However, biology is not entirely governed by soluble signals: Cells also respond to mechanical cues in the microenvironment, actively changing shape and cytoskeletal organization (7) and adjusting adhesion affinity (8) when matrix tension or stiffness change.”
Environmental sensing through focal adhesions (2009, background): “Thus, cells can react to internally generated or externally applied force”
The myofibroblast: paradigm for a mechanically active cell. (2010, background): “Transition of such nascent adhesions into mature FAs is also driven by mechanical force exerted by contractile actin–myosin stress fibers and a mechanically resistant ECM (Bershadsky et al., 2003; Chen et al., 2004).”
Multi-electrode array technologies for neuroscience and cardiology. (2013, background): “For these reasons, intensive efforts were devoted to increase the value of R seal (refs 35,37,39) .”
Physics of adherent cells (2013, background): “If a cell encounters an external surface covered with specific ligand, it undergoes a multi-step process that determines whether or not it eventually will adhere (Bershadsky et al., 2003; Cohen et al., 2004).”
A bio-mechanical model for coupling cell contractility with focal adhesion formation (2008, background): “Although the nature of mechanical sensing by FA is not fully understood, several possible mechanisms have been proposed (Bershadsky et al., 2003; Zhu et al., 2000) and a number of phenomenological models have been developed that account for the growth of FAs with increasing traction forces at the…”
Activation of a vinculin‐binding site in the talin rod involves rearrangement of a five‐helix bundle (2004, background): “External mechanical force has been shown to induce focal adhesion assembly (Bershadsky et al, 2003), and talin is essential for this process and for the recruitment of vinculin to fibronectin-coated glass beads (Giannone et al, 2003).”
Mechanical tugging force regulates the size of cell–cell junctions (2010, background): “Yet, unlike the mechanosensitivity of focal adhesions (18), forcedependent assembly of cadherins cell–cell junctions is not well established.”
Matrix elasticity directs stem cell lineage specification. (2006, background): “Such a wide variation in matrix stiffness for differentiated cells is known to influence focal-adhesion structure and the cytoskeleton (Bershadsky et al., 2003; Cukierman et al., 2001; Discher et al., 2005; Engler et al., 2004a; Lo et al., 2000; Pelham and Wang, 1997).”
Intermediate filaments: from cell architecture to nanomechanics (2007, background): “The collagen fibrils of the ECM are linked to the interior of cells by hemidesmosomes and focal adhesions”
Review on Cell Mechanics: Experimental and Modeling Approaches (2013, background): “Transactions of the ASME predominately at focal adhesions, which are protein complexes that have both a structural and mechanosignaling role [41].”
Micropatterning as a tool to decipher cell morphogenesis and functions (2010, background): “Above a critical length of cell spreading, cells will form stress fibers between adhesion sites, which will grow and mature into focal adhesions (Bershadsky et al., 2003).”