Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission

By S. Floresco, A. R. West, B. Ash, H. Moore, Anthony A. Grace. Nature Neuroscience, 2003

1,152 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bd2426f428edda34b7b893dbb70a7efbf9951e46

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Citations in the corpus

The principal features and mechanisms of dopamine modulation in the prefrontal cortex. (2004, background): “Midbrain DA neurons fire in regular single spikes and in occasional phasic bursts, which are regulated by diverse afferents in vivo (Grace and Bunney, 1983, 1984; Grace, 2002; Kosobud et al., 1994; Overton and Clark, 1997; Floresco et al., 2003).”
Dopamine release in the basal ganglia (2011, background): “Similarly, the DAT has greater influence on larger transients after multiple-vesicle release from single or multiple sites, demonstrated by the greater effect of DAT inhibition on [DA]o during increased phasic DA neuron activity compared to a simple increase in the rate of tonic firing (Gonon, 1988;”
Burst timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons: A putative cellular substrate for reward learning (2009, neutral): “, 2006),and hippocampus, though this may be through ventral pallidum via an indirect basal ganglia loop (Floresco et al., 2003; Lisman and Grace, 2005; Lodge and Grace, 2006a, 2007, 2008).”
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. (2008, positive): “Thus, based on the combination of our functional and molecular data, the fast-firing mesocorticolimbic DA neurons with a low dopamine reuptake capacity appear well suited to mediate the often sustained forms of behaviorally relevant DA release in vivo in several brain regions (Bassareo et al., 2002;”
The nucleus accumbens: an interface between cognition, emotion, and action. (2015, background): “…DA release in the extrasynaptic or “tonic” DA levels change on relatively slow timescales (minutes), 108 180 regulated by the overall number of DA neurons that are active and can also be modulated by excitatory presynaptic inputs locally within the NAc (Floresco et al. 2003, Howland et al. 2002).”
Dopamine System Dysregulation in Major Depressive Disorders (2017, background): “These bursts are driven by afferents from regions such as the pedunculopontine tegmental nucleus (PPTg), a glutamatergic/cholinergic structure (Floresco et al., 2003; Lodge and Grace, 2006b), and the laterodorsal tegmentum (Lodge and Grace, 2006a).”
Computational models of reinforcement learning: the role of dopamine as a reward signal (2010, background): “…to in the literature, evidences for tonic changes in DA concentrations (e.g. long lasting, timescales of seconds to minutes) have also been reported in vivo, in the basal ganglia and in prefrontal cortices (PFC; Bergstrom and Garris 2003; Floresco et al. 2003; Goto and Grace 2005; Grace 1991).”
The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes (2004, background): “According to the tonic/ phasic model, high-amplitude phasic DA released by behaviorally driven bursts of action potentials within subcortical systems is regulated by fast reuptake via the DAT (Floresco et al, 2003; Grace, 1991, 1993; Moore et al, 1999).”
Reconsidering Anhedonia in Depression: Lessons from Translational Neuroscience (2010, background): “As additionally outlined in figure 1, initiation of phasic activity requires excitatory signals from a variety of areas, including the prefrontal cortex, pedunculpontinetegmentum (PPt) and subthalamic nucleus (Floresco et al., 2003; Futami et al., 1995; Smith and Grace, 1992) as well as suppression ”
The Brain on Drugs: From Reward to Addiction. (2015, background): “, 2014), whereas the control of phasic firing of VTA DA neurons involves the pedunculo pontine tegmentum (PPT), the subthalamic nucleus (STN), and the laterodorsal tegmentum (Floresco et al., 2003; Lodge and Grace, 2006).”
Neuronal Reward and Decision Signals: From Theories to Data. (2015, background): “The activations may have derived from dopamine neurons or not; the 30–45% of dopamine neurons lacking spontaneous activity (76, 166, 176, 211) may include nonactivated neurons and thus go undetected while taking up the label.”
Multiple dopamine functions at different time courses. (2007, background): “Burst firing of dopamine neurons depends on NMDA receptors ( Johnson et al. 1992) and excitatory inputs from nucleus pedunculopontinus (Scarnati et al. 1984, Kelland et al. 1993, Floresco et al. 2003, Lodge & Grace 2006a) and the laterodorsal tegmental nucleus (Lodge & Grace 2006b).”
Reinforcement learning in the brain (2009, background): “However, dopamine neurons operate in both a phasic and a tonic mode (Grace, 1991; Weiner & Joel, 2002; Floresco et al., 2003; Bergstrom & Garris, 2003; Goto & Grace, 2005), and affect not only synaptic plasticity, but also membrane potentials and neural excitability (which may be particularly sensit”
Cortico-Basal Ganglia Reward Network: Microcircuitry (2009, positive): “…are also consistent with electrophysiological evidence that the PPTg–LDT complex excites DA cells and promotes burst firing (Futami et al, 1995; Lokwan et al, 1999; Floresco et al, 2003; Lodge and Grace, 2006b) (see 'Limbic modulation of VTA DA neuron activity' in section Ventral tegmental area).”