Toward defining the autoimmune microbiome for type 1 diabetes

By A. Giongo, K. Gano, David B. Crabb, Nabanita Mukherjee, L. L. Novelo, George Casella, Jennifer C. Drew, J. Ilonen, M. Knip, H. Hyöty and 8 more. The ISME Journal, 2011

789 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bce1eb81ccbd1ef52b948354325a592435e5ef51

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Citations in the corpus

Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications. (2012, background): “Much of the initial research focus on the microbiome has been on understanding disease (Chang et al., 2008; Giongo et al., 2011; Sepehri et al., 2007; Young et al., 2011).”
Intestinal microbiota of healthy and unhealthy Atlantic salmon Salmo salar L. in a recirculating aquaculture system (2018, background): “A reduction in microbial diversity will reduce the set of ecosystem processes available, such as a reduced capacity to digest a diverse diet, causing lower energy levels and reduced resistance to pathogens by the host (Giongo et al., 2011).”
Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease (2012, background): “genetically susceptible infants who develop T1D also have lower microbial diversity than those who do not develop the disease [94].”
The Dynamics of the Human Infant Gut Microbiome in Development and in Progression towards Type 1 Diabetes (2015, positive): “…development may have a role in promoting susceptibility to or protection from disease later in life; this has been demonstrated in mice (Cho et al., 2012; Cox et al., 2014), and it may also be true for type 1 diabetes (T1D) (Brown et al., 2011; Giongo et al., 2011; de Goffau et al., 2013).”
Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes (2011, methodology): “The samples used in this study came from eight Finnish children described previously [22].”
The Impact of the Gut Microbiota on Human Health: An Integrative View (2012, neutral): “Compared with non-autoimmune individuals, children at high genetic risk for diabetes exhibit a distinct composition of the gut microbiota, with decreased diversity over time and higher relative abundances of Bacteroides ovatus and firmicute strain CO19 (Giongo et al., 2011 ).”
Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis (2016, background): “Among the environmental associations linked to type 1 diabetes are enteroviral and other infections (51,52) and altered intestinal microbiome composition (53).”
Current understanding of dysbiosis in disease in human and animal models (2016, background): “Although IDDM and NIDDM are caused by different mechanisms in the body, studies have found that both types have dysbiosis of the intestinal microbiota, which may contribute to the pathogenesis of the disease.(28) IDDM-associated dysbiosis is characterized by a decrease in mucin degrading bacteria, B”
Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study (2013, background): “These authors showed a successive decline in Firmicutes and an increase in Bacteroidetes number in the gut microbiome over time until the children became diabetic [21].”