Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis

By J. Skyler, G. Bakris, E. Bonifacio, T. Darsow, R. Eckel, Leif Groop, P. Groop, Y. Handelsman, R. Insel, C. Mathieu and 7 more. Diabetes, 2016

707 citations recorded by the source corpus.

The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, “The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis” on 10–12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic and environmental determinants of type 1 and type 2 diabetes risk and progression, as well as complications. The participants debated how to determine appropriate therapeutic approaches based on disease pathophysiology and stage and defined remaining research gaps hindering a personalized medical approach for diabetes to drive the field to address these gaps. The authors recommend a structure for data stratification to define the phenotypes and genotypes of subtypes of diabetes that will facilitate individualized treatment.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Physiology

View Paper: https://www.semanticscholar.org/paper/66334978df497cc6c1b32d68048cdc49097d2a38

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Citations in the corpus

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2018 (2017, background): “Future classification schemes for diabetes will likely focus on the pathophysiology of the underlying b-cell dysfunction and the stage of disease as indicated by glucose status (normal, impaired, or diabetes) (4).”
2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023. (2022, background): “Three distinct stages of type 1 diabetes can be identi ﬁ ed ( Table 2.1 ) and serve as a framework for research and regulatory decision-making (12,15).”
2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021. (2020, background): “1) and serve as a framework for future research and regulatory decision-making (8,10).”