Differential projections of the infralimbic and prelimbic cortex in the rat

By Robert P. Vertes. Synapse, 2004

1,531 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/bcbd0ef6b5ec48f912c9e0c791312cbdbe2d2dc8

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Fear extinction in rats: implications for human brain imaging and anxiety disorders. (2006, background): “Indeed, the vmPFC is ideally situated for expression of extinction because it sends robust projections to the amygdala (McDonald, 1998; Vertes, 2004).”
Prefrontal involvement in the regulation of emotion: convergence of rat and human studies. (2006, background): “The IL targets the ITC cells and central-lateral amygdala [38] (both inhibitory), whereas the PL targets the basal subdivision of the amygdala [38,39], which is necessary for fear expression [40].”
Learned Helplessness at Fifty: Insights from Neuroscience (2016, background): “…complexity of detecting the presence of control suggests a cortical process, and the dorsal raphe nucleus receives virtually all of its cortical input from the prelimbic region (PL) of the ventromedial prefrontal cortex (vmPFC; Peyron, Petit, Rampon, Jouvet, & Luppi, 1998; Vertes, 2004).”
Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward. (2005, background): “Moreover, gustatory and viscerosensory regions within agranular insular cortex also project densely to the infralimbic and prelimbic regions of medial prefrontal cortex, which, in turn, project strongly to the Acb [7–10].”
Prefrontal mechanisms in extinction of conditioned fear. (2006, neutral): “The infralimbic subregion of mPFC has extensive projections to the amygdala, as well as the amygdala’s targets in the hypothalamus and brainstem (Floyd et al 2001; Hurley et al 1991; Vertes 2004).”
Psychobiological Mechanisms Underlying the Social Buffering of the HPA Axis: A Review of Animal Models and Human Studies across Development (2013, background): “This brain area has strong reciprocal connections with the amygdala and can modulate the PVN (Figueiredo et al., 2003; Stefanacci & Amaral, 2002; Vertes, 2004).”
Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear (2010, neutral): “Thus, PL and vHPC can serve as modulators of fear expression through their projections to BLA. vHPC could modulate BLA either directly (Pitkanen et al., 2000) or indirectly via the PL (Vertes, 2004; Gabbott et al., 2005).”
Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear. (2006, background): “…does not project to BA, but instead projects to GABAergic cells in the lateral subdivision of the central nucleus (CeL) and intercalated (ITC) cell masses of the amygdala (Cassell and Wright 1986; Sesack et al. 1989; Hurley et al. 1991; McDonald et al. 1996; Freedman et al. 2000; Vertes 2004).”
Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus (2005, background): “Anatomically, the DRN receives virtually all of its cortical input from infralimbic (IL) and prelimbic (PL) regions within the mPFC”
Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety (2010, positive): “The mPFC then projects directly to structures such as the amygdala and the periaqueductal gray (Vertes, 2004), which can act to produce appropriate defensive behaviors.”
Impulsivity, compulsivity, and top-down cognitive control. (2011, neutral): “Clearly, there are several ways by which top-down control may be implemented: from the Il-PFC or the hippocampus to the shell, from the PL-PFC to the core and by currently unspeciﬁed interactions between the core and shell regions, either directly or indirectly via ‘‘spiralling cascades’’ of striato”
Brain mediators of cardiovascular responses to social threat, Part I: Reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity (2009, background): “, 1996; Vertes, 2004)— the PL to the basolateral amygdala, associated with fear learning, and the IL to intercalated inhibitory neurons in the amygdala (Vertes, 2004), which are associated with the suppression of fear behavior during extinction.”